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Tetraethylene glycol monotosylate

  Cat. No.:  DC29013   Featured
Chemical Structure
77544-60-6
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Field of application
Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 77544-60-6
Chemical Name: 2-(2-(2-(2-Hydroxyethoxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulfonate
Synonyms: 2-(2-(2-(2-Hydroxyethoxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulfonate;2-[2-[2-(2-HYDROXYETHOXY)ETHOXY]ETHOXY]-1-(P-TOLUENESULFONYL)-ETHANOL;Ethanol,2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 1-(4-methylbenzenesulfonate);[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethyl-4-methylbenzenesulfonate;tetraethyleneglycol monotosylate;tetraglycol-Ts;toluene-4-sulfonic acid 2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethyl ester;Ts-tetraglycol;Tetraethylene glycol p-toluenesulfonate
SMILES: CC1C=CC(S(OCCOCCOCCOCCO)(=O)=O)=CC=1
Formula: C15H24O7S
M.Wt: 348.411864280701
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Target: Cleavable
In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References: [1]. Park KD, et al. Useful tools for biomolecule isolation, detection, and identification: acylhydrazone-based cleavable linkers.Chem Biol. 2009 Jul 31;16(7):763-72.
MSDS
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MSDS_13063_DC29013_77544-60-6
COA
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Cat. No. Product name Field of application
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DC42440 Fmoc-Gly-Gly-Phe-OH Fmoc-Gly-Gly-Phe-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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DC41150 Fmoc-3VVD-OH Fmoc-3VVD-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
DC41143 MC-Gly-Gly-Phe-Gly MC-Gly-Gly-Phe-Gly is a cleavable ADC linker used for antibody-drug conjugates (ADCs).
DC40831 Fmoc-Val-Ala-PAB-PNP Fmoc-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
DC40614 Maleimide-DOTA Maleimide-DOTA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
DC29217 N-Boc-diethanolamine N-Boc-diethanolamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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