Cas No.: | 77544-60-6 |
Chemical Name: | 2-(2-(2-(2-Hydroxyethoxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulfonate |
Synonyms: | 2-(2-(2-(2-Hydroxyethoxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulfonate;2-[2-[2-(2-HYDROXYETHOXY)ETHOXY]ETHOXY]-1-(P-TOLUENESULFONYL)-ETHANOL;Ethanol,2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 1-(4-methylbenzenesulfonate);[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethyl-4-methylbenzenesulfonate;tetraethyleneglycol monotosylate;tetraglycol-Ts;toluene-4-sulfonic acid 2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethyl ester;Ts-tetraglycol;Tetraethylene glycol p-toluenesulfonate |
SMILES: | CC1C=CC(S(OCCOCCOCCOCCO)(=O)=O)=CC=1 |
Formula: | C15H24O7S |
M.Wt: | 348.411864280701 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. |
Target: | Cleavable |
In Vitro: | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
References: | [1]. Park KD, et al. Useful tools for biomolecule isolation, detection, and identification: acylhydrazone-based cleavable linkers.Chem Biol. 2009 Jul 31;16(7):763-72. |