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Desmorpholinyl Quizartinib-PEG2-COOH

  Cat. No.:  DC40522  
Chemical Structure
2292116-14-2
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More than 5000 active chemicals with high quality for research!
Field of application
Desmorpholinyl Quizartinib-PEG2-COOH incorporates a ligand for FLT-3, and a PEG-based PROTAC linker. Desmorpholinyl Quizartinib-PEG2-COOH can be used in the synthesis of PROTAC FLT-3 degrader 1. PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM.
Cas No.: 2292116-14-2
Chemical Name: 3-(2-(2-((2-(4-(3-(5-(Tert-Butyl)isoxazol-3-yl)ureido)phenyl)benzo[d]imidazo[2,1-b]thiazol-7-yl)oxy)ethoxy)ethoxy)propanoic acid
Synonyms: 3-(2-(2-((2-(4-(3-(5-(tert-Butyl)isoxazol-3-yl)ureido)phenyl)benzo[d]imidazo[2,1-b]thiazol-7-yl)oxy)ethoxy)ethoxy)propanoic acid;Desmorpholinyl Quizartinib-PEG2-COOH
SMILES: S1C2C([H])=C(C([H])=C([H])C=2N2C([H])=C(C3C([H])=C([H])C(=C([H])C=3[H])N([H])C(N([H])C3C([H])=C(C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])ON=3)=O)N=C12)OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])C(=O)O[H]
Formula: C30H33N5O7S
M.Wt: 607.6773
Purity: >98%
Sotrage: Powder-20°C3 years4°C2 yearsIn solvent-80°C6 months -20°C1 month
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