DL-AP4

  Cat. No.:  DC10707   Featured
Chemical Structure
6323-99-5
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More than 5000 active chemicals with high quality for research!
Field of application
DL-AP4 is a Broad spectrum EAA antagonist.
Cas No.: 6323-99-5
Chemical Name: DL-2-Amino-4-phosphonobutanoic acid (AP4)
Synonyms: 2-amino-4-phosphonobutanoic acid;2-amino-4-phosphonobutyric acid;DL-2-Amino-4-phosphonobutanoic acid (AP4)
SMILES: C(CP(=O)(O)O)C(C(=O)O)N
Formula: C4H10NO5P
M.Wt: 183.099662303925
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: DL-AP4 (2-Amino-4-phosphonobutyric acid) is a glutamate antagonist. DL-AP4 behaves as a competitive inhibitor of glutamate binding with an apparent Kd of 66 μM. DL-AP4 can be used for the research of central nervous system and visual system[1][2][3].
In Vitro: DL-AP4 (500 μM) reduces the tonic inward current by closing ion channels at holding potentials of -33 mV in isolated rod bipolar cells[1]. DL-AP4 (0.1 M; 1h) antagonizes the excitatory action of glutamate applied iontophoretically to receptors present in the locust muscle membrane[2]. DL-AP4 (compound 2) antagonizes excitatory synapses in the lateral perforant path of the rat hippocampal slice with an apparent Kd of 2.5 μM[3].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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