DL-AP4|CAS: 20263-07-4|DC Chemials

Cas No.:	6323-99-5
Chemical Name:	DL-2-Amino-4-phosphonobutanoic acid (AP4)
Synonyms:	2-amino-4-phosphonobutanoic acid;2-amino-4-phosphonobutyric acid;DL-2-Amino-4-phosphonobutanoic acid (AP4)
SMILES:	C(CP(=O)(O)O)C(C(=O)O)N
Formula:	C₄H₁₀NO₅P
M.Wt:	183.099662303925
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

DL-AP4 (2-Amino-4-phosphonobutyric acid) is a glutamate antagonist. DL-AP4 behaves as a competitive inhibitor of glutamate binding with an apparent Kd of 66 μM. DL-AP4 can be used for the research of central nervous system and visual system[1][2][3].

In Vitro:

DL-AP4 (500 μM) reduces the tonic inward current by closing ion channels at holding potentials of -33 mV in isolated rod bipolar cells[1]. DL-AP4 (0.1 M; 1h) antagonizes the excitatory action of glutamate applied iontophoretically to receptors present in the locust muscle membrane[2]. DL-AP4 (compound 2) antagonizes excitatory synapses in the lateral perforant path of the rat hippocampal slice with an apparent Kd of 2.5 μM[3].

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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