Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) |cas 96027-74-6| DC Chemicals

Cas No.:	96027-74-6
Chemical Name:	Desethylamiodarone hydrochloride
Synonyms:	Methanone,(2-butyl-3-benzofuranyl)[4-[2-(ethylamino)ethoxy]-3,5-diiodophenyl]-,hydrochloride (1:1);Desethyl Amiodarone Hydrochloride;(2-butyl-1-benzofuran-3-yl)-[4-[2-(ethylamino)ethoxy]-3,5-diiodophenyl]methanone,hydrochloride;(2-Butylbenzofuran-3-yl)(4-(2-(ethylamino)ethoxy)-3,5-diiodophenyl)methanone hydrochloride;Methanone,(2-butyl-3-benzofuranyl)[4-[2-(ethylamino)ethoxy]-3,5-diiodophenyl]-,hydrochloride (...;N-Desethylamiodarone (hydrochloride);N-Desethylamiodarone hydrochloride solution;desethylamiodarone;mono-N-desethylamiodarone hydrochloride;Amiodarone
SMILES:	Cl.CCNCCOC1C(I)=CC(C(C2=C(CCCC)OC3=CC=CC=C23)=O)=CC=1I
Formula:	C₂₃H₂₆Cli₂NO₃
M.Wt:	653.719390392303
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is a major active metabolite of Amiodarone. Desethylamiodarone hydrochloride is formed by CYP3A isoenzymes. Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM[1][2][3].

References:

[1]. Shayeganpour A, et al. Determination of the enzyme(s) involved in the metabolism of amiodarone in liver and intestine of rat: the contribution of cytochrome P450 3A isoforms. Drug Metab Dispos. 2006 Jan;34(1):43-50. [2]. Singh, B.N. and E.M. Vaughan Williams, The effect of amiodarone, a new anti-anginal drug, on cardiac muscle. Br J Pharmacol, 1970. 39(4): p. 657-67. [3]. Rosenbaum, M.B., et al., Clinical efficacy of amiodarone as an antiarrhythmic agent. Am J Cardiol, 1976. 38(7): p. 934-44.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101
2018-0101

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