Diminutol|cas 361431-33-6|DC Chemicals

Cas No.:	361431-33-6
Chemical Name:	(2R)-2-[[6-[(3-aminophenyl)thio]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
Synonyms:	NG72
SMILES:	OC[C@@H](C(C)C)NC1=NC2=C(N=CN2C(C)C)C(SC3C=C(N)C=CC=3)=N1
Formula:	C₁₉H₂₆N₆Os
M.Wt:	386.5
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Diminutol is a cell-permeable 2,6,9-trisubstituted purine analog that blocks mitotic spindle assembly by competitively inhibiting NQO1, an NADP-dependent oxidoreductase. Diminutol has been shown to interact with the NADP binding site and directly affect tubulin polymerization. Diminutol does not induce oxidative stress or affect the activity of Cdk1, DNA replication, or actin polymerization. Diminutol has been shown to cause significant microtubule depolymerization in Xenopus XL177 cells at 50μM.

MSDS

COA

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2018-0101

Cat. No.	Product name	Field of application
DC47250	Nonanal	Nonanal is a saturated fatty aldehyde with antidiarrhoeal activity.
DC47249	Piperitone	Piperitone is as a powerful repellent and antiappetent agent. Piperitone is very toxic to Cymbopogon schoenanthus (C. schoenanthus) adults, newly laid eggs and to neonate larvae. Insecticidal activity.
DC47247	Tyrosylleucine TFA	Tyrosylleucine (Tyr-Leu, YL) TFA, an orally active dipeptide, exhibits a potent antidepressant-like activity.
DC47243	Dehydroglyasperin C	Dehydroglyasperin C, a isoflavone, is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C has antioxidant, neuroprotective, cancer chemopreventive, and anti-inflammatory activities.
DC47227	(−)-Myrtenal	(−)-Myrtenal ((1R)-(−)-Myrtenal) is an orally active terpene with antitumour activity. (−)-Myrtenal ameliorates hyperglycemia by enhancing GLUT2 through Akt in the skeletal muscle and liver of diabetic rats.
DC47224	GPX4-IN-3	GPX4-IN-3 (26a) is a potent glutathione peroxidase 4 (GPX4) inhibitor as a selective ferroptosis inducer. GPX4-IN-3 (26a) exhibits 71.7% inhibition for GPX4 with 1 μM.
DC47179	Tyrosylleucine	Tyrosylleucine (Tyr-Leu, YL), an orally active dipeptide, exhibits a potent antidepressant-like activity.
DC47178	Mead acid	Mead acid (5,8,11-Eicosatrienoic acid), an unsaturated (Omega-9) fatty acid, is an indicator of essential fatty acid deficiency.
DC47140	Yadanzioside K	Yadanzioside K is a natural quassinoid glucoside found in Brucea amarissima.
DC47105	Complanatoside B	Complanatoside B is a P. chinense Fisch flavonoid with potential anti-inflammatory effects.