Diquafosol tetrasodium

  Cat. No.:  DC10343   Featured
Chemical Structure
211427-08-6
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More than 5000 active chemicals with high quality for research!
Field of application
Diquafosol tetrasodium is a P2Y2 receptor agonist that stimulates fluid and mucin secretion on the ocular surface, as a topical treatment of dry eye disease.
Cas No.: 211427-08-6
Chemical Name: P1,P4-Di(uridine-5′-tetraphosphate)
Synonyms: P1,P4-Di(uridine-5′-tetraphosphate);Diquafosol tetrasodium;INS-365;DE-089;Prolacria;tetrasodium [[[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]oxy-oxido-phosphoryl]oxy-oxido-phosphoryl] [(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl phosphate;INS365;tetrasodium [[[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-oxido-phosphoryl]oxy-oxido-phosphoryl]oxy-oxido-phosphoryl] [(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-;Luliconazole;Diquafosol (tetrasodium)
SMILES: O[C@H]([C@@H]([C@@H](COP(OP(OP(OP(OC[C@@H]1[C@H]([C@@H](O)[C@H](O1)N2C(NC(C=C2)=O)=O)O)([O-])=O)([O-])=O)([O-])=O)([O-])=O)O3)O)[C@@H]3N(C(N4)=O)C=CC4=O.[Na+].[Na+].[Na+].[Na+]
Formula: C18H22N4O23P4-4.4[Na+]
M.Wt: 878.234680000001
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Cell viability significantly decreased after treatment with 30% diluted diquafosol for 1 hour and 6 hours after treatment with 10% and 20% diluted diquafosol. Twenty-four hours after wounding monolayers, 3% diquafosol, and 0.3% HCECs exhibits significantly more wound healing than the control.In a rat dry eye model, the P2Y2 agonist diquafosol tetrasodium is found to improve surface health, based on increases in tear fluid secretion, corneal epithelial resistance, and release of glycoprotein-containing moieties from goblet cells. Beginning at 2 weeks and continuing for an additional 2 weeks, maximal declines in dye penetrance of approximately 50% occurred with doses of diquafosol tetrasodium as low as 1%. INS365 significantly suppresses corneal damage at concentrations of more than 0.1% w/v.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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