Dorzolomide hydrochloride

Cas No.:	130693-82-2
Chemical Name:	4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, hydrochloride
Synonyms:	Trusopt, Cosopt
SMILES:	CCN[C@H]1C[C@@H](S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)C.Cl
Formula:	C10H16N2O4S3.HCl
M.Wt:	360.9
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Dorzolamide (trade name Trusopt) is a carbonic anhydrase inhibitor. It is an anti-glaucoma agent and topically applied in the Form of eye drops. This drug, developed by Merck, was the first drug in human therapy (market introduction 1995) which resulted from structure-based drug design. Dorzolamide hydrochloride is used to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension. The combination of dorzolamide with timolol is marketed under the trade name Cosopt. TRUSOPT (dorzolamide hydrochloride ophthalmic solution) is a carbonic anhydrase inhibitor Formulated For topical ophthalmic use. Dorzolamide hydrochloride is described chemically as: (4S-trans)-4-(ethylamino)-5,6-dihydro-6-methyl4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide monohydrochloride. Dorzolamide hydrochloride is optically active. The specific rotation is α 25° (C=1, water) = ~ -17° Its empirical Formula is C10H16N2O4S3•HCl. Dorzolamide hydrochloride has a molecular weight of 360.9 and a melting point of about 264°C. It is a white to off-white, crystalline powder, which is soluble in water and slightly soluble in methanol and ethanol. TRUSOPT Sterile Ophthalmic Solution is supplied as a sterile, isotonic, buffered, slightly viscous, aqueous solution of dorzolamide hydrochloride. The pH of the solution is approximately 5.6, and the osmolarity is 260-330 mOsM. Each mL of TRUSOPT 2% contains 20 mg dorzolamide (22.3 mg of dorzolamide hydrochloride). Inactive ingredients are hydroxyethyl cellulose, mannitol, sodium citrate dihydrate, sodium hydroxide (to adjust pH) and water For injection. Benzalkonium chloride 0.0075% is added as a preservative. For the detailed information about the solubility of Dorzolomide hydrochloride in water, the solubility of Dorzolomide hydrochloride in DMSO, the solubility of Dorzolomide hydrochloride in PBS buffer, the animal experiment（test） of Dorzolomide hydrochloride, the in vivo,in vitro and clinical trial test of Dorzolomide hydrochloride, the cell experiment（test） of Dorzolomide hydrochloride, the IC50, EC50 and Affinity of Dorzolomide hydrochloride , please contact DC Chemicals.For the detailed information of Dorzolomide hydrochloride, the solubility of Dorzolomide hydrochloride in water, the solubility of Dorzolomide hydrochloride in DMSO, the solubility of Dorzolomide hydrochloride in PBS buffer, the animal experiment (test) of Dorzolomide hydrochloride, the cell expriment (test) of Dorzolomide hydrochloride, the in vivo, in vitro and clinical trial test of Dorzolomide hydrochloride, the EC50, IC50,and Affinity of Dorzolomide hydrochloride, Please contact DC Chemicals.