Droxinostat|cas 99873-43-5|DC Chemicals

Cas No.:	99873-43-5
Chemical Name:	4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide
Synonyms:	Droxinostat;4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide;Droxinostat ( NS41080);NS 41080;NS-41080;MLS000109046;SMR000104993;XCH;NS41080;CBMicro_030914;CBChromo1_000102;MLS006011918;GTPL8464;cid_568416;Droxinostat, >=98% (HPLC);BDBM53719;JHSXDAWGLCZYSM-UHFFFAOYSA-N;HMS3260P20;HMS3654J06;BCPP000249;HMS2177P11;BCP23435;Tox21_500319;STK945834;s1422;BCP9000629;NCGC00087387-
SMILES:	ClC1C([H])=C([H])C(=C(C([H])([H])[H])C=1[H])OC([H])([H])C([H])([H])C([H])([H])C(N([H])O[H])=O
Formula:	C₁₁H₁₄ClNO₃
M.Wt:	243.6868
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Selective HDAC3, HDAC6 and HDAC8 inhibitor (IC50 values are 16.9, 2.47 and 1.46 μM for HDAC3, 6 and 8 respectively). Induces apoptosis. Shows antitumor effects in vivo. For the detailed information of Droxinostat, the solubility of Droxinostat in water, the solubility of Droxinostat in DMSO, the solubility of Droxinostat in PBS buffer, the animal experiment (test) of Droxinostat, the cell expriment (test) of Droxinostat, the in vivo, in vitro and clinical trial test of Droxinostat, the EC50, IC50,and affinity,of Droxinostat, For the detailed information of Droxinostat, the solubility of Droxinostat in water, the solubility of Droxinostat in DMSO, the solubility of Droxinostat in PBS buffer, the animal experiment (test) of Droxinostat, the cell expriment (test) of Droxinostat, the in vivo, in vitro and clinical trial test of Droxinostat, the EC50, IC50,and affinity,of Droxinostat, Please contact DC Chemicals.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
DC70802	SS-208	SS-208 (SS208) is a novel potent, selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 12 nM, >100-fold selectivity over HDAC1/4/5/7/8/9/11.SS-208 has minimal effects on the viability of murine SM1 melanoma cells in vitro, significantly reduced in vivo tumor growth in a murine SM1 syngeneic melanoma mouse model.
DC3110	CUDC-907 (PI3K/HDAC InhibitorI)	CUDC-907 (PI3K/HDAC Inhibitor I) is a dual PI3K and HDAC inhibitor for PI3Kɑ, HDAC1, HDAC2, HDAC3 and HDAC10 with IC50 of 19 nM, 1.7 nM, 5 nM, 1.8 nM and 2.8 nM, respectively.
DC8252	Vorinostat (SAHA)	Vorinostat (SAHA) is an HDAC1/3 inhibitor with IC50 of ~10 nM.
DC8663	UF010	UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively. It has > 6-fold selectivity over other HDACs.
DC6303	Tubastatin A HCl	Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold).
DC6304	Tubastatin A	Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold).
DC5178	Tubacin (BML-GR362)	Tubacin is a selective inhibitor of HDAC6 via inhibition of the second deacetylase domain (DD2).
DC8134	Trichostatin A (TSA)	Trichostatin A (TSA) is a selective and potent HDAC inhibitor with IC50 of ~1.8 nM; HDAC8 is the only known member of the HDAC-family that is not affected by TSA.
DC7716	TMP269	TMP269 is a novel and selective class IIa histone deacetylase inhibitor with IC50s of 126/80/36/9 nM for HDAC 4/5/7/9, respectively; 20-400 fold selectivity over class1 HDACs.
DC10210	TMP195	TMP195 is the most potent and selective class IIa HDAC inhibitor.