| Description: |
Epothilone A, discovered from the myxobacterium Sorangium cellulosum, is a Taxol-like microtubule-stabilizing agent that induces tubulin polymerization, leading to cell cycle arrest at the G2-M transition, cytotoxicity, and apoptosis. Epothilone A potently inhibits cell proliferation in HCT116 cells, with IC50 of 4.4 nM.Epothilone A also displays cytotoxicity in KB3-1, KBV-1, Hela, and Hs578T cells, with IC50 values ranging from 13 nM to 160 nM. Epothilone A is more water soluble than Taxol and competes with Taxol in binding with microtubules, with IC50 of 2.3 μM. However, both Epothilone A and Taxol don't share a common pharmacophore and exploits the tubulin-binding pocket uniquely and independently. Recently, it is found that microbiological trans Formation of Epothilone A by Aspergillus niger AS 3.739 yields several metabolites that is also toxic to MCF-7 cells, but with much higher IC50 values. For the detailed information of Epothilone A, the solubility of Epothilone A in water, the solubility of Epothilone A in DMSO, the solubility of Epothilone A in PBS buffer, the animal experiment (test) of Epothilone A, the cell expriment (test) of Epothilone A, the in vivo, in vitro and clinical trial test of Epothilone A, the EC50, IC50,and Affinity of Epothilone A, Please contact DC Chemicals. |
