Indacaterol Maleate|cas 753498-25-8|supplier DC Chemicals

Cas No.:	753498-25-8
Chemical Name:	(R)-5-(2-((5,6-diethyl-2,3-dihydro-1H-inden-2-yl)amino)-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one maleate
Synonyms:	QAB-149; QAB 149; QAB149; Indacaterol maleate; trade name Onbrez Breezhale; arcapta neohaler; Onbrez.
SMILES:	O=C1NC2=C(C([C@@H](O)CNC3CC4=C(C=C(CC)C(CC)=C4)C3)=CC=C2O)C=C1.O=C(O)/C=CC(O)=O
Formula:	C₂₈H₃₂N₂O₇
M.Wt:	508.571
Purity:	99%
Sotrage:	2 years -20°C powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

In vitro: Indacaterol inhibits cAMP production in Chinese hamster ovary cells stably transfected with human β2 adrenoceptors with pEC50 of 8.06. Indacaterol inhibits electrically induced contraction on the electrically stimulated guinea pig trachea in a concentration-dependent manner with pEC50 of 8.23. Indacaterol induces a concentration-dependent inotropic effect with maximal efficacy of 75% in the isolated guinea pig left atrium.Indacaterol reverses the carbachol-induced contraction in a concentration-dependent manner with IC50 of 37 nM in human small airways. Indacaterol concentration dependently reverses the serotonin-induced contraction with IC50 of 10.5 nM in rat small airways. Indacaterol has the highest intrinsic efficacy of 53% in rat small airways and 73% in human small airways. Indacaterol (10 μM) induces close to full inhibition of the EFS-induced contraction of isolated human bronchi and the effect lasts 12 hours.Indacaterol inhibits the IgE-dependent release of histamine from mast cells with the intrinsic activity (Emax of a long-acting Indacaterol/Emax of Isoprenaline) of 1.03. Indacaterol inihbits cAMP release from human airway smooth muscle with pEC50 of 8.53 and Emax of 48%. Indacaterol appears to have a reduced efficacy compared with the CHO-K1 data in the primary ASM cells. In vivo:Indacaterol (6.7 μg/kg) inhibits 5-HT-induced bronchoconstriction with a maximal effect of 85% in the conscious guinea pig. Indacaterol (12.5 μg/kg) dose-dependently inhibits methacholine-induced bronchoconstriction with a maximal effect of 85% in the anesthetized rhesus monkey.For the detailed information of Indacaterol Maleate, the solubility of Indacaterol Maleate in water, the solubility of Indacaterol Maleate in DMSO, the solubility of Indacaterol Maleate in PBS buffer, the animal experiment (test) of Indacaterol Maleate, the cell expriment (test) of Indacaterol Maleate, the in vivo, in vitro and clinical trial test of Indacaterol Maleate, the EC50, IC50,and Affinity of Indacaterol Maleate, Please contact DC Chemicals.

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2018-0101

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