Irinotecan hydrochloride trihydrate

  Cat. No.:  DC4153  
Chemical Structure
136572-09-3
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More than 5000 active chemicals with high quality for research!
Field of application
Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1.
Cas No.: 136572-09-3
Chemical Name: (S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride trihydrate.
Synonyms: CPT11; CPT-11; CPT 11; U101440E; HSDB 7607; HSDB-7607; HSDB7607; camptothecin-11; irinotecan; irinotecan HCl; Bbrand name: Camptosa; Campto.
SMILES: O=C(N1CCC(N2CCCCC2)CC1)OC3=CC4=C(CC)C(CN5C(C(COC([C@@]6(CC)O)=O)=C6C=C57)=O)=C7N=C4C=C3.[H]Cl.[H]O[H].[H]O[H].[H]O[H]
Formula: C33H45ClN4O9E
M.Wt: 677.19
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: For the detailed information about the solubility of Irinotecan hydrochloride trihydrate in water, the solubility of Irinotecan hydrochloride trihydrate in DMSO, the solubility of Irinotecan hydrochloride trihydrate in PBS buffer, the animal experiment(test) of Irinotecan hydrochloride trihydrate,the in vivo,in vitro and clinical trial test of Irinotecan hydrochloride trihydrate,the cell experiment(test) of Irinotecan hydrochloride trihydrate,the IC50, EC50 and Affinity of Irinotecan hydrochloride trihydrate, please contact DC Chemicals.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC47325 Huanglongmycin N Huanglongmycin N is a DNA topoisomerase I inhibitor (EC50 = 14 μM).
DC46831 T-2513 hydrochloride T-2513 hydrochloride is a selective topoisomerase I inhibitor. T-2513 hydrochloride binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death.
DC46830 Intoplicine dimesylate Intoplicine (RP 60475) dimesylate, an antitumor derivative in the 7H-benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor. Intoplicine dimesylate strongly binds DNA (KA = 2 x 105 /M) and thereby increases the length of linear DNA.
DC45986 Hippeastrine Hippeastrine, an active alkaloid, exhibits a good dose-dependent inhibitory effect against topoisomerase I (Top I) with an IC50 at 7.25 μg/mL. Antiproliferative and anticancer activities.
DC45556 (±)-Evodiamine (±)-Evodiamine, a quinazolinocarboline alkaloid, is a Top1 inhibitor. Evodiamine exhibits anti-inflammatory, antiobesity, and antitumor effects. (±)-Evodiamine inhibits the proliferation of a wide variety of tumor cells by inducing their apoptosis.
DC45283 Coralyne chloride Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage. Coralyne chloride can be used for preparing coralyne derivatives as DNA binding fluorescent probes.
DC44139 PluriSIn #2 PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs).
DC42296 Exatecan D5 Mesylate Exatecan D5 Mesylate (DX8951f-D5) is deuterium labeled Exatecan Mesylate. Exatecan Mesylate is a DNA topoisomerase I, with an IC50 of 0.975 μg/mL.
DC41162 Gimatecan Gimatecan (ST1481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.
DC41116 Merbarone Merbarone (NSC 336628) is an orally active inhibitor of topoisomerase II. Merbarone acts primarily by blocking topoisomerase II-mediated DNA cleavage. Merbarone is an anticancer agent.
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