Jatrorrhizine hydroxide

  Cat. No.:  DC41298  
Chemical Structure
483-43-2
For research use only. We do not sell to patients.
We match the best price and quality on market.
Email:order@dcchemicals.com  sales@dcchemicals.com
Tel:+86-021-58447131
We are official vendor of:
  • 20
  • 19
  • 18
  • 17
  • 16
  • 15
  • 14
  • 12
  • 11
  • 10
  • 9
  • 8
  • 13
  • 6
  • 5
  • 4
  • 3
  • 2
  • 1
More than 5000 active chemicals with high quality for research!
Field of application
Jatrorrhizine?hydroxide is an alkaloid isolated from?Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities. Jatrorrhizine hydroxide is a potent and orally active inhibitor of?AChE?(IC50=872 nM) over >115-fold selectivity for BuChE. Jatrorrhizine hydroxide reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters.
Cas No.: 483-43-2
Chemical Name: Jatrorrhizine hydroxide
SMILES: COC1=C(OC)C2=C[N+]3=C(C4=CC(OC)=C(O)C=C4CC3)C=C2C=C1.[OH-]
Formula: C20H21NO5
M.Wt: 355.38
Sotrage: 4°C, protect from light*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC47776 Millmerranone A Millmerranone A shows the acetylcholinesterase inhibitory property.
DC47775 Chikusetsusaponin Ib Chikusetsusaponin Ib has anti-Alzheimer's disease activity and is a potent AChE inhibitor.
DC47774 Cyclopenin Cyclopenin ((±)-Isocyclopenine) is a racemate.
DC47773 Cyclanoline chloride Cyclanoline (chloride) shows cholinesterase inhibitory activity.
DC47772 Isonaringin Isonaringin shows anti-Alzheimer’s activity by inhibiting AChE.
DC47239 Zanapezil free base Zanapezil (TAK-147) free base is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil free base shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC50=51.2 nM). Zanapezil free base shows a moderate inhibition of muscarinic M1 and M2 receptor binding with Ki values of 234 and 340 nM, respectively. Zanapezil free base can be used for the research of early stages of Alzheimer's disease (AD).
DC46568 Acotiamide D6 Acotiamide D6 is a deuterium labeled Acotiamide. Acotiamide is an orally active and first-in-class gastroprokinetic agent for the treatment of functional dyspepsia.
DC46069 Echimidine N-oxide Echimidine N-oxide, a pyrrolizidine alkaloid, has acetylcholinesterase (AChE) inhibitory activity (IC50=0.347 mM).
DC45995 Manghaslin Manghaslin is a flavonoid glycoside with anti-inflammatory activities. Manghaslin shows inhibitory activity against AChE with an IC50 of 94.92 µM.
DC44782 O-Desmethyl Galanthamine O-Desmethyl Galanthamine (Sanguinine) is galanthamine-type alkaloid. O-Desmethyl Galanthamine is an acetylcholinesterase (AChE) inhibitor, with an IC50 1.83 μM.
X