KCL-440|KCL440, KB-78015|Provide by DC CHEM

Cas No.:	651029-09-3
Chemical Name:	4-[4-[(dimethylamino)methyl]phenyl]-5-hydroxy-2H-isoquinolin-1-one
Synonyms:	CTK2A0007, KCL 440, KB-78015
SMILES:	O=C1NC=C(C2=CC=C(CN(C)C)C=C2)C3=C(O)C=CC=C31
Formula:	C₁₈H₁₈N₂O₂
M.Wt:	294.3477
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

KCL-440 is a possible neuroprotective agent with high blood-brain barrier permeability and high PARP inhibitory activity. KCL-440 exhibited potency with regard to inhibition of PARP activity, with an IC50 value of 68 nM. For the detailed information of KCL-440, the solubility of KCL-440 in water, the solubility of KCL-440 in DMSO, the solubility of KCL-440 in PBS buffer, the animal experiment (test) of KCL-440, the cell expriment (test) of KCL-440, the in vivo, in vitro and clinical trial test of KCL-440, the EC50, IC50,and affinity,of KCL-440, Please contact DC Chemicals.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC47395	CEP-9722	CEP-9722, the prodrug of CEP-8983, is a selective and orally active PARP-1 and PARP-2 inhibitor with IC50s of 20 nM and 6 nM, respectively. CEP-9722 has anticancer effects.
DC47394	PARP1-IN-6	PARP1-IN-6 is a dual tubulin/PARP-1 inhibitor with IC50 values of 0.94 and 0.48 μM, respectively.
DC47393	PARP/EZH2-IN-1	PARP/EZH2-IN-1 is a first-in-class dual PARP (IC50 6.87 nM) and EZH2 (IC50 36.51 nM) inhibitor for triple-negative breast cancer with wild-type BRCA.
DC47211	TC-E 5001	TC-E 5001 is an inhibitor of Wnt pathway that inhibits tankyrase 1/2 (TNKS1/2) via novel adenosine pocket binding, with Kds of 79 nM and 28 nM, respectively. TC-E 5001 also inhibits Axin2 and STF, with IC50s of 0.709 μM and 0.215 μM, respectively.
DC46429	PARP1-IN-5	PARP1-IN-5 is a low toxicity, orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 can be used for the research of cancer.
DC46428	PARP1-IN-5 dihydrochloride	PARP1-IN-5 dihydrochloride is a low toxicity, orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer.
DC45192	Olaparib D8	Olaparib D8 (AZD2281 D8) is the deuterium labeled Olaparib (AZD2281). Olaparib is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator.
DC42488	2-Methylquinazolin-4-ol	2-Methylquinazolin-4-ol is a potent competitive poly(ADP-ribose) synthetase inhibitor, with a Ki of 1.1 μM. 2-Methylquinazolin-4-ol mammalian aspartate transcarbamylase (ATCase) inhibitor, with 0.20 mM.
DC42294	Senaparib	Senaparib (IMP4297) is a highly potent, selective and orally active PARP1/2. Senaparib (IMP4297) exhibits strong antitumor activity in animal models.
DC40457	Fluorescein-NAD+	Fluorescein-NAD+ is an alternative to radiolabeled NAD and a substrate for ADP-ribosylation. Fluorescein-NAD+ can be used in PARP assays by fluorescence microscopy. Extinction Coefficient: 262 nm.