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KPT-185

  Cat. No.:  DC7445  
Chemical Structure
1333151-73-7
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More than 5000 active chemicals with high quality for research!
Field of application
KPT-185 is an orally bioavailable selective inhibitor of CRM1 amd displayes potent antiproliferative properties at submicromolar concentrations,induced apoptosis (average 5-fold increase), cell-cycle arrest, and myeloid differentiation in AML cell lines a
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1333151-73-7
Chemical Name: 2-Propenoic acid, 3-[3-[3-methoxy-5-(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-, 1-methylethyl ester, (2Z)-
Synonyms: KPT185; KPT 185
SMILES: O=C(OC(C)C)/C=CN1N=C(C2=CC(C(F)(F)F)=CC(OC)=C2)N=C1
Formula: C16H16F3N3O3
M.Wt: 355.31
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: KPT-185 significantly inhibits leukemia cell proliferation with IC50 ranging from 100 nM to 500 nM, and induces cell-cycle arrest and apoptosis of AML cell lines and primary AML blasts. KPT-185 reduces CRM1 protein protein level and shows a significant nuclear accumulation of CRM1 cargo proteins. KPT-185 also inhibits proliferation and promotes apoptosis of pancreatic cancer cells without affecting human pancreatic ductal epithelial cells. For the detailed information of KPT-185, the solubility of KPT-185 in water, the solubility of KPT-185 in DMSO, the solubility of KPT-185 in PBS buffer, the animal experiment (test) of KPT-185, the cell expriment (test) of KPT-185, the in vivo, in vitro and clinical trial test of KPT-185, the EC50, IC50,and Affinity of KPT-185, Please contact DC Chemicals.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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