L-826,266|cas 244101-03-9

Cas No.:	244101-03-9
Synonyms:	L-826,266
SMILES:	ClC(C=C1/C=C/C(NS(C2=C(OC)C=CC(Br)=C2)(=O)=O)=O)=CC=C1CC3=CC4=CC=CC=C4C=C3
Formula:	C₂₇H₂₁BrClNO₄S
M.Wt:	570.9
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

L-826,266 is a potent and selective competitive antagonist of the prostaglandin E2 receptor subtype EP3 (Ki = 0.8 nM).It also binds to the EP4 receptor (Ki = 715 nM) but does not bind to EP1 or EP2 receptors up to a concentration of 5,000 nM. L-826,266 inhibits vasoconstriction induced by the EP3 agonist sulprostone in a concentration-dependent manner (EC50s = 0.45-24.5 µM in isolated human pulmonary arteries).It also inhibits sulprostone-induced norepinephrine and serotonin release in rat cortex and norepinephrine release in rat vas deferens (pA2s = 7.56, 7.67, and 7.87, respectively).

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC42503	Taprenepag isopropyl	Taprenepag isopropyl is a highly selective EP2 receptor agonist.
DC47374	Aligeron	Aligeron is a non-selective prostaglandin (PG) antagonist, and has vasodilatory properties.
DC47373	CAY10580	CAY10580 is a potent and selective prostaglandin EP4 receptor agonist (Ki=35 nM).
DC47183	Aganepag isopropyl	Aganepag isopropyl (AGN-210961) is an EP2 agonist.
DC47172	15-Keto latanoprost	15-Keto latanoprost is a metabolite of Latanoprost, which is an ocular hypotensive agent.
DC47127	Pexopiprant	Pexopiprant is an oral antagonist of the prostaglandin D2 receptor 2 (DP2),Ki ＜ 100nM. Pexopiprant can be used in studies of asthma.
DC47089	Treprostinil palmitil	Treprostinil palmitil (TP) is the prodrug of DP1 and EP2 agonist, Treprostinil (UT-15), whose EC50 values were 0.6 and 6.2 nM, respectively. Treprostinil palmitil is a pure prodrug and possesses no inherent binding to G-protein coupled receptors including prostanoid receptors.
DC46853	BGC-20-1531 free base	BGC-20-1531 (PGN 1531) free base is a potent and selective prostanoid EP4 receptor antagonist, with a pKb of 7.6. BGC-20-1531 free base has the potential for the research of migraine headache.
DC46564	Bimatoprost D5	Bimatoprost D5 (AGN 192024 D5) is a deuterium labeled Bimatoprost. Bimatoprost is a prostaglandin analog and is a topical hypotensive agent frequently used for treating ocular hypertension and glaucoma. Bimatoprost also has an antiadipogenic effect.
DC45799	TCS 2510	TCS 2510 is a selective EP4 agonist. TCS 2510 can be used for the research of metabolic diseases.