MF498

Cas No.:	915191-42-3
Chemical Name:	N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide
Synonyms:	MF498,MF-498,MF 498
SMILES:	O=C1N(C2=C(C)C=C(CS(NC(CC3=CC=CC=C3OC)=O)(=O)=O)C=C2)CC4=C(OCC)C5=NC=CC=C5C(OCC)=C41
Formula:	C32H33N3O7S
M.Wt:	603.7
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

MF498 is a selective EP4 receptor antagonist (Ki = 0.7 nM versus a Ki > 1 µM for other EP receptors).In HEK293 cells expressing the human EP4 receptor, MF498 inhibits EP ligand induced activity with an IC50 value of 1.7 nM.In various animal models for arthritis, MF498 has been shown to inhibit inflammation without gastrointestinal toxicity (ED50 values as low as 0.02 mg/kg/day). For the detailed information of MF498, the solubility of MF498 in water, the solubility of MF498 in DMSO, the solubility of MF498 in PBS buffer, the animal experiment (test) of MF498, the cell expriment (test) of MF498, the in vivo, in vitro and clinical trial test of MF498, the EC50, IC50,and affinity,of MF498, For the detailed information of MF498, the solubility of MF498 in water, the solubility of MF498 in DMSO, the solubility of MF498 in PBS buffer, the animal experiment (test) of MF498, the cell expriment (test) of MF498, the in vivo, in vitro and clinical trial test of MF498, the EC50, IC50,and affinity,of MF498, Please contact DC Chemicals.