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ML311

  Cat. No.:  DC12222   Featured
Chemical Structure
315698-17-0
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More than 5000 active chemicals with high quality for research!
Field of application
ML311 is a potent and selective inhibitor of the Mcl-1/Bim interaction.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 315698-17-0
Chemical Name: 7-[(4-Ethylpiperazin-1-yl)-[4-(trifluoromethyl)phenyl]methyl]quinolin-8-ol
Synonyms: ML311;7-[(4-ethylpiperazin-1-yl)-[4-(trifluoromethyl)phenyl]methyl]quinolin-8-ol;ML 311;7-((4-ethylpiperazin-1-yl)(4-(trifluoromethyl)phenyl)methyl)quinolin-8-ol;7-[(4-Ethyl-1-piperazinyl)[4-(trifluoromethyl)phenyl]methyl]-8-quinolinol;7-{(4-ethylpiperazin-1-yl)[4-(trifluoromethyl)phenyl]methyl}quinolin-8-ol;SMR000559037;MLS001198484;MLS004257019;HMS2858D15;BCP32653;STL487150
SMILES: FC(C1C([H])=C([H])C(=C([H])C=1[H])C([H])(C1C([H])=C([H])C2C([H])=C([H])C([H])=NC=2C=1O[H])N1C([H])([H])C([H])([H])N(C([H])([H])C([H])([H])[H])C([H])([H])C1([H])[H])(F)F
Formula: C23H24F3N3O
M.Wt: 415.4514
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: ML311 is a potent and selective inhibitor of the Mcl-1/Bim interaction.
Target: Mcl-1 Bim
In Vitro: ML311 potently halts viability of several types of Mcl-1 primed cells, including MCL-1-1780 (EC50=0.31 μM), DHL-6 (EC50=3.3 μM), and NCI-H929 (EC50=1.6 μM), with generally high maximal effect (>80%). ML311 also displays activity in a leukemia-derived cell line particularly reliant upon Bcl-2 function (Bcl2-1863, EC50=1.1 μM). ML311 has strong growth inhibitory effects in many cell lines, with GI50<900 nM for nine cell types (RPMI-8226, SR, NCI-H322M, NCI-H60, HCC-2998, KM12, SF-295, U251, PC-3 cell lines), and <2 μM for 14 additional types[1].
References: [1]. Bannister T, et al. ML311: A Small Molecule that Potently and Selectively Disrupts the Protein-Protein Interaction of Mcl-1 and Bim: A Probe for Studying Lymphoid Tumorigenesis. Biotechnology Information (US); 2010-2012 Apr 16
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
2018-0101
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