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MS48107

  Cat. No.:  DC80088   Featured
Chemical Structure
2375070-79-2
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More than 5000 active chemicals with high quality for research!
Field of application
MS4-8107 is a potent and selective positive allosteric modulator of G protein-coupled receptor 68 (GPR68). MS48107 is selective for GPR68 over the closely related proton GPCRs, neurotransmitter transporters, and hERG ion channels. MS 48107 can readily cross the blood-brain barrier (BBB) in mice[1].
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2375070-79-2
Chemical Name: (2-(4-Amino-6-((4-phenoxybenzyl)amino)-1,3,5-triazin-2-yl)-3-fluorophenyl)methanol
Synonyms: (2-(4-Amino-6-((4-phenoxybenzyl)amino)-1,3,5-triazin-2-yl)-3-fluorophenyl)methanol;GTPL10440;BDBM50528405;MS48107;compound 71 [PMID: 31298539]
SMILES: FC1=C([H])C([H])=C([H])C(C([H])([H])O[H])=C1C1=NC(N([H])[H])=NC(=N1)N([H])C([H])([H])C1C([H])=C([H])C(=C([H])C=1[H])OC1C([H])=C([H])C([H])=C([H])C=1[H]
Formula: C23H20FN5O2
M.Wt: 417.4356
Purity: >95%
Publication: [1]. Xufen Yu, et al. Design, Synthesis, and Characterization of Ogerin-Based Positive Allosteric Modulators for G Protein-Coupled Receptor 68 (GPR68). J Med Chem. 2019 Aug 22;62(16):7557-7574.
Description: MS48107 is a potent and selective positive allosteric modulator of G protein-coupled receptor 68 (GPR68). MS48107 is selective for GPR68 over the closely related proton GPCRs, neurotransmitter transporters, and hERG ion channels. MS48107 can readily cross the blood-brain barrier (BBB) in mice[1].
References: [1]. Xufen Yu, et al. Design, Synthesis, and Characterization of Ogerin-Based Positive Allosteric Modulators for G Protein-Coupled Receptor 68 (GPR68). J Med Chem. 2019 Aug 22;62(16):7557-7574.
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