MSDC-0602|MSDC0602

Cas No.:	1133819-87-0
Chemical Name:	5-(4-(2-(3-methoxyphenyl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione
Synonyms:	MSDC-0602; MSDC0602; MSDC 0602
SMILES:	O=C(N1)SC(CC2=CC=C(OCC(C3=CC=CC(OC)=C3)=O)C=C2)C1=O
Formula:	C₁₉H₁₇NO₅S
M.Wt:	371.08
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

MSDC-0602, a PPARγ-sparing thiazolidinedione (TZD), interacts with the mitochondrial pyruvate carrier (MPC) and inhibits its activity and are effective for treatment of type 2 diabetes with reducing risk of PPARγ-mediated side effects[1][2].

References:

[1]. Chen Z, et al. Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione. J Biol Chem. 2012 Jul 6;287(28):23537-48. [2]. Vigueira PA, et al. The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism. Exp Physiol. 2017 Aug 1;102(8):985-999.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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