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NE 10790 (3-PEHPC)

  Cat. No.:  DC12348   Featured
Chemical Structure
152831-36-2
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More than 5000 active chemicals with high quality for research!
Field of application
NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 152831-36-2
SMILES: OC(C(O)=O)(P(O)(O)=O)CC1=CC=CN=C1
Formula: C8H10NO6P
M.Wt: 247.14
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent.
Target: FPP synthase[1].
In Vitro: NE 10790 inhibits incorporation of [14C]mevalonic acid into Rab6, but not into H-Ras or Rap1, proteins that are modified by FTase and GGTase I, respectively. NE 10790 reduces viability in J774 cells. NE 10790 prevents prenylation of 22-26-kDa proteins that are not modified by FTase or GGTase I[1].
References: [1]. Coxon FP, et al. Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages. J Biol Chem. 2001 Dec 21;276(51):48213-22.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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