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NMS-E973

  Cat. No.:  DC33535   Featured
Chemical Structure
1253584-84-7
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More than 5000 active chemicals with high quality for research!
Field of application
NMS-E973 is a novel, selective and potent inhibitor of heat shock protein 90 (Hsp90). NMS-E973 displays significant efficacy in a human ovarian A2780 xenograft tumor model, with a mechanism of action confirmed in vivo by typical modulation of known Hsp90 client proteins, and with a favorable pharmacokinetic and safety profile. The efficacy profile of NMS-E973 suggests a potential for development in different clinical settings, including tumors that have become resistant to molecular targeted agents, particularly in cases of tumors which reside beyond the blood-brain barrier (BBB).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1253584-84-7
Chemical Name: Nms-e973
Synonyms: NMS-E 973;NMS-E973;(5E)-5-[2-hydroxy-6-(4-nitrophenoxy)-4-oxocyclohexa-2,5-dien-1-ylidene]-N-(1-methylpiperidin-4-yl)-2H-1,2-oxazole-3-carboxamide;HMS3653E08;BRD-K58770988-001-01-8;MS-28264;GLXC-04054;AKOS027307871;1253584-84-7;SCHEMBL657965;SW220107-1;NMSE973; NMS E973;C22H22N4O7;CS-0009348;s7282;5-[(1E)-2-hydroxy-6-(4-nitrophenoxy)-4-oxocyclohexa-2,5-dien-1-ylidene]-N-(1-methylpiperidin-4-yl)-2H-1,2-oxazole-3-carboxamide;SB19443;PD156195;9UN;G14369;HY-17547;PD118025;DA-66152;Q27457049;EX-A4406;CCG-269277;5-[2,4-Dihydroxy-6-(4-Nitrophenoxy)phenyl]-N-(1-Methylpiperidin-4-Yl)-1,2-Oxazole-3-Carboxamide;NMS E973;NCGC00386326-01;5-[2,4-Dihydroxy-6-(4-nitrophenoxy)phenyl]-N-(1-methyl-4-piperidinyl)-3-isoxazolecarboxamide;BCP29502;5-(2,4-Dihydroxy-6-(4-nitrophenoxy)phenyl)-N-(1-methylpiperidin-4-yl)-isoxazole-3-carboxamide;BDBM50442760;CHEMBL2443044;NMS-973
SMILES: O=C(C1=NOC(C2=C(OC3=CC=C([N+]([O-])=O)C=C3)C=C(O)C=C2O)=C1)NC4CCN(C)CC4
Formula: C22H22N4O7
M.Wt: 454.433
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_15846_DC33535_1253584-84-7
COA
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