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Naloxegol Oxalate(NKTR-118)

  Cat. No.:  DC8492   Featured
Chemical Structure
1354744-91-4
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More than 5000 active chemicals with high quality for research!
Field of application
Naloxegol is the first oral peripherally acting mu opioid receptor antagonists for opioid-induced constipation.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1354744-91-4
Chemical Name: (4R,4aS,7S,7aR,12bS)-7-((2,5,8,11,14,17,20-heptaoxadocosan-22-yl)oxy)-3-allyl-1,2,3,4,5,6,7,7a-octahydro-4aH-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol oxalate
Synonyms: NKTR-118; NKTR 118; NKTR118; AZ-13337019; AZ13337019; AZ 13337019; EGylated naloxol; Naloxegol Oxalate; trade names Movantik and Moventig.
SMILES: COCCOCCOCCOCCOCCOCCOCCO[C@H]1CC[C@]2([C@H]3CC4=C5[C@]2([C@H]1OC5=C(C=C4)O)CCN3CC=C)O.C(=O)(C(=O)O)O
Formula: C36H55NO15
M.Wt: 741.828
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Naloxegol oxalate (NKTR-118 oxalate; AZ-13337019 oxalate) is an opioid-receptor antagonist[1].
Target: Opioid receptor[1]
References: [1]. Garnock-Jones KP, et al. Naloxegol: a review of its use in patients with opioid-induced constipation. Drugs. 2015 Mar;75(4):419-25. [2]. Yoon SC, et al. Naloxegol in opioid-induced constipation: a new paradigm in the treatment of a common problem. Patient Prefer Adherence. 2017 Jul 24;11:1265-1271.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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