| Description: |
Netupitant is a highly potent and selective, orally active neurokinin-1 receptor antagonist with Ki of 0.95 nM.
IC50 value: 0.95 nM (Ki)
in vitro: Netupitant also dose-dependently inhibited the SP response as expected from an NK1 receptor antagonist. Importantly, when both palonosetron and netupitant were present, they exhibited an enhanced inhibition of the SP response compared to either of the two antagonists alone.
in vivo: In mice the intrathecal injection of SP elicited the typical scratching, biting and licking response that was dose-dependently inhibited by Netupitant given intraperitoneally in the 1-10mg/kg dose range. In gerbils, foot tapping behavior evoked by the intracerebroventricular injection of a NK(1) agonist was dose-dependently counteracted by Netupitant given intraperitoneally (ID(50) 1.5mg/kg) or orally (ID(50) 0.5mg/kg). For the detailed information of Netupitant, the solubility of Netupitant in water, the solubility of Netupitant in DMSO, the solubility of Netupitant in PBS buffer, the animal experiment (test) of Netupitant, the cell expriment (test) of Netupitant, the in vivo, in vitro and clinical trial test of Netupitant, the EC50, IC50,and affinity,of Netupitant, For the detailed information of Netupitant, the solubility of Netupitant in water, the solubility of Netupitant in DMSO, the solubility of Netupitant in PBS buffer, the animal experiment (test) of Netupitant, the cell expriment (test) of Netupitant, the in vivo, in vitro and clinical trial test of Netupitant, the EC50, IC50,and affinity,of Netupitant, Please contact DC Chemicals. |
