Nitisinone|NTBC|4-hydroxyphenylpyruvate dioxygenase inhibitor

Cas No.:	104206-65-7
Chemical Name:	NTBC;Nitisone;SC0735;Orfadin
Synonyms:	NTBC;Nitisone;SC0735;Orfadin
SMILES:	C1CC(=O)C(C(=O)C1)C(=O)C2=C(C=C(C=C2)C(F)(F)F)[N+](=O)[O-]
Formula:	C₁₄H₁₀F₃NO₅
M.Wt:	329.2281
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Nitisinone(SC0735) is an inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase.Nitisinone is a drug used to slow the effects of hereditary tyrosinemia type 1. Nitisinone reduced urinary HGA levels from an average of 4.0 +/- 1.8 (SD) g/day to 0.2 +/- 0.2 g/day ( P < .001). Low-dose nitisinone effectively reduced urinary HGA levels in patients with alkaptonuria. Future long-term clinical trials are planned to determine the benefits of nitisinone in preventing joint deterioration and providing pain relief, and its long-term side effects [1]. Nitisinone can prevent the development of liver disease and significantly reduce the risk of developing hepatocellular carcinoma; however, vigorous surveillance for the development of HCC needs to be continued lifelong [2].

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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