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OGG1 inhibitor O8

  Cat. No.:  DC12526   Featured
Chemical Structure
350997-39-6
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More than 5000 active chemicals with high quality for research!
Field of application
OGG1 inhibitor O8 is a potent, selective inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with IC50 of 0.22 uM, displays no significant activity against other DNA Glycosylases (NEIL1, NTH1, Fpg, IC50>50 uM)..
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 350997-39-6
Chemical Name: 3,4-dichlorobenzo[b]thiophene-2-carbohydrazide
SMILES: C12=CC=CC(Cl)=C1C(Cl)=C(C(NN)=O)S2
Formula: C9H6Cl2N2Os
M.Wt: 261.12
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: OGG1-IN-08 is a potent 8-oxoguanine DNA glycosylase-1 (OGG1) inhibitor with an IC50 value of 0.22 μM. OGG1-IN-08 decreases both the glycosylase and lyase activities of OGG1[1].
Target: IC50: 0.22 μM (OGG1)[1]
In Vitro: OGG1-IN-08 (50 μM) inhibits different DNA glycosylases activities, it inhibits nei endonuclease VIII-like 1 DNA glycosylase (NEIL1)(84.56%), endonuclease III-like (NTH1)(63.09%), and Fpg (91.74%), respectively[1]. OGG1-IN-08 (10 μM) has a inhibitory OGG1 lyase activity on a substrate containing an AP site compared with the no inhibitor control[1]. OGG1-IN-08 (10 μM) decreases the number of bases released into solution by OGG1 for both the 8-oxo-Gua and FapyGua compared with the no inhibitor[1].
References: [1]. Nathan Donley,et al. Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1). ACS Chem Biol. 2015 Oct 16;10(10):2334-43.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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