ONO-AE3-208|cas 402473-54-5|DC Chemicals

Cas No.:	402473-54-5
Synonyms:	AE 3-208;ONO AE3 208
SMILES:	N#CC1=CC=C(C(NC(C(C2=C3C=CC=CC3=C(F)C=C2)C)=O)=C1)CCCC(O)=O
Formula:	C₂₄H₂₁FN₂O₃
M.Wt:	404.4335
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

ONO-AE3-208(AE 3-208) is an EP4 antagonist; suppresses cell invasion, migration, and metastasis of prostate cancer. EP4 over-expressing LNCaP was established, and their cell invasiveness was compared with the control LNCaP (LNCaP/mock). The in vitro cell proliferation, invasion, and migration of these cells were examined under different concentrations of ONO-AE3-208. An in vivo bone metastatic mouse model was constructed by inoculating luciferase expressing PC3 cells into left ventricle of nude mice. Their bone metastasis was observed by bioluminescent imaging with or without ONO-AE3-208 administration. The EP4 mRNA expression levels were higher in PC3 than in LNCaP, and EP4 over-expression of LNCaP cells enhanced their cell invasiveness. Arachidonic acid caused dose-dependent dilation of the attached Af-Art (from 8.6 ± 1.2 to 15.3 ± 0.7 μm; P<0.001; n=6), and this effect was blocked by ONO-AE3-208 (10(-7) mol/L).

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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