Oncrasin 1 |75629-57-1 |DC Chemicals

Cas No.:	75629-57-1
Chemical Name:	1-(4-Chlorobenzyl)-1H-indole-3-carbaldehyde
Synonyms:	1-(4-Chlorobenzyl)-1H-indole-3-carbaldehyde;Oncrasin 1;1-[(4-chlorophenyl)methyl]indole-3-carbaldehyde;1-[(4-Chlorophenyl)methyl]-1H-indole-3-carboxaldehyde;1-(4-Chlorobenzyl)-1H-indole-3-carboxaldehyde;Oncrasin-1;1-(4-Chloro-benzyl)-1H-indole-3-carbaldehyde;Oncrasin1;Cambridge id 5601604;N-4-chlorobenzyl-3-formylindole;ZDRQMXCSSAPUMM-UHFFFAOYSA-N;HMS3677L20;HMS3413L20;ALB
SMILES:	ClC1C([H])=C([H])C(=C([H])C=1[H])C([H])([H])N1C([H])=C(C([H])=O)C2=C([H])C([H])=C([H])C([H])=C12
Formula:	C₁₆H₁₂ClNO
M.Wt:	269.7256
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Oncrasin 1 is a proapoptotic substance. Induces abnormal nuclear aggregation of PKCι and suppressing RNA transcription. Displays antiproliferative effects against various human tumor cell lines. Shown to inhibit human xenograft growth by 75% in vivo. For the detailed information of Oncrasin 1, the solubility of Oncrasin 1 in water, the solubility of Oncrasin 1 in DMSO, the solubility of Oncrasin 1 in PBS buffer, the animal experiment (test) of Oncrasin 1, the cell expriment (test) of Oncrasin 1, the in vivo, in vitro and clinical trial test of Oncrasin 1, the EC50, IC50,and affinity,of Oncrasin 1, For the detailed information of Oncrasin 1, the solubility of Oncrasin 1 in water, the solubility of Oncrasin 1 in DMSO, the solubility of Oncrasin 1 in PBS buffer, the animal experiment (test) of Oncrasin 1, the cell expriment (test) of Oncrasin 1, the in vivo, in vitro and clinical trial test of Oncrasin 1, the EC50, IC50,and affinity,of Oncrasin 1, Please contact DC Chemicals.

References:

[1]. Guo W, et al. Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota. Cancer Res. 2008 Sep 15;68(18):7403-8. [2]. Guo W, et al. Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1). Mol Cancer Ther. 2009 Feb;8(2):441-8.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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