Oritavancin(LY-333328,Orbactiv)|DC Chemicals

Cas No.:	937-13-3
Synonyms:	LY333328; LY-333328; LY 333328; Oritavancin; brand name: Orbactiv
SMILES:	C[C@H]1[C@@H]([C@@](C[C@@H](O1)O[C@H]2[C@H]3C(=O)N[C@@H](C4=CC(=CC(=C4C5=C(C=CC(=C5)[C@H](C(=O)N3)NC(=O)[C@H]6C7=CC(=C(C(=C7)OC8=C(C=C(C=C8)[C@H]([C@H](C(=O)N[C@H](C(=O)N6)CC(=O)N)NC(=O)[C@@H](CC(C)C)NC)O)Cl)O[C@H]9[C@@H](C([C@@H]([C@H](O9)CO)O)O)O
Formula:	C₈₆H₁₀₃Cl₃N₁₀O₃₄P₂
M.Wt:	1989.1
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Oritavancin, also known as LY333328 and Orbactiv, is a novel semisynthetic glycopeptide antibiotics. On August 6, 2014, the FDA approved oritavancin for treatment of skin infections. Oritavancin possesses potent and rapid bactericidal activity in vitro against a broad spectrum of both resistant and susceptible Gram-positive bacteria, including Staphylococcus aureus, MRSA, enterococci, and streptococci. Oritavancin was more active than either metronidazole or vancomycin against strains of Clostridium difficile tested. Oritavancin has potential use as a therapy for exposure to Bacillus anthracis, the Gram-positive bacterium that causes anthrax, having demonstrated efficacy in a mouse model both before and after exposure to the bacterium. The 4'-chlorobiphenylmethyl group disrupts the cell membrane of Gram-positive bacteria. It also acts by inhibition of transglycosylation and inhibition of transpeptidation For the detailed information of Oritavancin Diphosphate（LY333328, Orbactiv）, the solubility of Oritavancin Diphosphate（LY333328, Orbactiv） in water, the solubility of Oritavancin Diphosphate（LY333328, Orbactiv） in DMSO, the solubility of Oritavancin Diphosphate（LY333328, Orbactiv） in PBS buffer, the animal experiment (test) of Oritavancin Diphosphate（LY333328, Orbactiv）, the cell expriment (test) of Oritavancin Diphosphate（LY333328, Orbactiv）, the in vivo, in vitro and clinical trial test of Oritavancin Diphosphate（LY333328, Orbactiv）, the EC50, IC50,and affinity,of Oritavancin Diphosphate（LY333328, Orbactiv）, For the detailed information of Oritavancin Diphosphate（LY333328, Orbactiv）, the solubility of Oritavancin Diphosphate（LY333328, Orbactiv） in water, the solubility of Oritavancin Diphosphate（LY333328, Orbactiv） in DMSO, the solubility of Oritavancin Diphosphate（LY333328, Orbactiv） in PBS buffer, the animal experiment (test) of Oritavancin Diphosphate（LY333328, Orbactiv）, the cell expriment (test) of Oritavancin Diphosphate（LY333328, Orbactiv）, the in vivo, in vitro and clinical trial test of Oritavancin Diphosphate（LY333328, Orbactiv）, the EC50, IC50,and affinity,of Oritavancin Diphosphate（LY333328, Orbactiv）, Please contact DC Chemicals.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
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DC31079	PPI149	Abarelix is a synthetic decapeptide and antagonist of naturally occurring gonadotropin-releasing hormone (GnRH). Abarelix directly and competitively binds to and blocks the gonadotropin releasing hormone receptor in the anterior pituitary gland, thereby inhibiting the secretion and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH). In males, the inhibition of LH secretion prevents the release of testosterone. As a result, this may relieve symptoms associated with prostate hypertrophy or prostate cancer, since testosterone is required to sustain prostate growth.
DC31078	Asulam	Asulam is a wild oat herbicide used in prairie regions for control of wild oats in cereal grains such as wheat.
DC31077	L-Leucic acid	Leucic acid, L- is a metabolite of the branched-chain amino acid leucine. It is commonly sold as a purported muscle building supplement. It also has fungicidal properties. HICA was shown to increase protein synthesis and muscle mass in rats who were recovering from a period of induced atrophy.
DC31076	Diisononyl phthalate	Diisononyl phthalate (DINP) is a phthalate used as a plasticizer. DINP is typically a mixture of chemical compounds consisting of various isononyl esters of phthalic acid.
DC31075	Ditridecyl phthalate	Ditridecyl phthalate is a phthalate ester. Phthalate esters are esters of phthalic acid and are mainly used as plasticizers, primarily used to soften polyvinyl chloride. They are found in a number of products, including glues, building materials, personal care products, detergents and surfactants, packaging, children's toys, paints, pharmaceuticals, food products, and textiles. Phthalates are hazardous due to their ability to act as endocrine disruptors.
DC31074	Isopropyl myristate	Isopropyl myristate is the ester of isopropyl alcohol and myristic acid.
DC31073	L-Butyrine	L-Butyrine is a member of the class of compounds known as L-alpha-amino acids. L-alpha-Amino acids are alpha amino acids which have the L-configuration of the alpha-carbon atom. L-alpha-aminobutyric acid is soluble (in water) and is a moderately acidic compound (based on its pKa). L-alpha-Aminobutyric acid is a non-proteogenic amino acid that can be found in the human kidney, in liver tissues, and in most biofluids or excreta (e.g. feces, breast milk, urine, and blood). Within the cell, L-alpha-aminobutyric acid is primarily located in the cytoplasm. alpha-Aminobutyric acid is biosynthesized by transaminating oxobutyrate, a metabolite in isoleucine biosynthesis. As a non-proteogenic amino acid, alpha-aminobutyric acid can be used by nonribosomal peptide synthases. One example of a nonribosomal peptide containing alpha-aminobutyric acid is ophthalmic acid, which was first isolated from calf lens. alpha-Aminobutyric acid is a non-essential amino acid that is primarily derived from the catabolism of methionine, threonine, and serine. High protein diets can result in significantly higher alpha-aminobutyrate levels in plasma (PMID: 26227325 ). alpha-Aminobutyric acid is elevated in the plasma of children with Reye's syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency (PMID: 420125 ). alpha-Aminobutyric acid is one of the three isomers of aminobutyric acid. The two other are the neurotransmitter gamma-aminobutyric acid (GABA) and beta-aminobutyric acid (BABA) which is known for inducing plant disease resistance.
DC31072	Amino-PEG8-alcohol	Amino-PEG8-alcohol is a PEG derivative containing an amino group with a hydroxyl group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. PEG Linkers may be useful in the development of antibody drug conjugates and drug delivery methods.
DC31071	Prochloraz	Prochloraz is a broad-spectrum contact imidazol fungicide used against several diseases in wheat, barley and oleaginous plants but also for treatment of flower production. It is a fungicide known to have multiple effects on the endocrine system of vertebrates.