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Oroxylin A

  Cat. No.:  DCQ-020   Featured
Chemical Structure
480-11-5
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More than 5000 active chemicals with high quality for research!
Field of application
>98%,Standard References
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 480-11-5
SMILES: OC(C1=C(C=C2O)OC(C3=CC=CC=C3)=CC1=O)=C2OC
Formula: C16H12O5
M.Wt: 284.26
Purity: >98%, Standard References Grade
Sotrage: 4°C for 1 year, -20°C for more than 2 years
Description: Oroxylin A is a natural active flavonoid with strong anticancer effects.
In Vivo: Oroxylin A inhibited the tumor growth of nude mice-inoculated MCF-7 or HCT116 cells. The expression of MDM2 protein in tumor tissue was downregulated by oroxylin A as well [1].
In Vitro: Oroxylin A suppressed the MDM2-mediated degradation of p53 via downregulating MDM2 transcription in wt-p53 cancer cells [1]. Oroxylin A remarkably reduced the generation of lactate and glucose uptake under hypoxia in HepG2 cells, inhibited HIF-1α expression and its stability [2]. Oroxylin A promotes superoxide dismutase (SOD2) gene expression through SIRT3-regulated DNA-binding activity of FOXO3a and increases the activity of SOD2 by promoting SIRT3-mediated deacetylation [3].
References: [1]. Zhao K, et al. Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells. J Hematol Oncol. 2015 Apr 23;8:41. http://www.ncbi.nlm.nih.gov/pubmed/25902914 [2]. Dai Q, et al. Oroxylin A regulates glucose metabolism in response to hypoxic stress with the involvement of Hypoxia-inducible factor-1 in human hepatoma HepG2 cells. Mol Carcinog. 2015 Aug 10. [3]. Wei L, et al. Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization. Cell Death Dis. 2015 Apr 9
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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