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PTC-209 hydrobromide

  Cat. No.:  DC8495   Featured
Chemical Structure
1217022-63-3
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Field of application
PTC-209 is a specific inhibitor for BMI-1 with IC50 of 0.5 uM in in both GEMS reporter and ELISA assays.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1217022-63-3
Chemical Name: N-(2,6-dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)thiazol-2-amine
Synonyms: PTC209; PTC 209
SMILES: S1C=C(C2N3C(=NC=2C)N=CC=C3)N=C1NC1=C(Br)C=C(OC)C=C1Br.[H]Br
Formula: C17H14Br3N5Os
M.Wt: 576.1
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: PTC-209 hydrobromide is a specific BMI-1 inhibitor with IC50 of 0.5 μM in both GEMS reporter and ELISA assays.
In Vivo: Pharmacokinetic analysis demonstrates that PTC-209 (60 mg/kg, subcutaneously once a day) effectively inhibits BMI-1 production in tumor tissue in vivo. Inhibition of BMI-1 with PTC-209 halts growth of preestablished tumors in vivo[1].
In Vitro: PTC-209 is a recently developed inhibitor of BMI1, in biliary tract cancer (BTC) cells. PTC-209 reduces overall viability in BTC cell lines in a dose-dependent fashion (0.04-20 μM). Treatment with PTC-209 leads to slightly enhanced caspase activity and stop of cell proliferation. Cell cycle analysis reveals that PTC-209 causes cell cycle arrest at the G1/S checkpoint[2]. PTC-209(100, 200, or 500nM) decreases BMI1 and increases p16 protein expression in canine OSA cell lines. Compare to vehicle control, BMI1 protein expression decreases by 40% and 25% in the Abrams and D17 cell lines, respectively, following 500 nM PTC-209 treatment. In the Moresco cell line, BMI1 protein expression decreases by 16% and 39% following 200nM and 500nM PTC-209 treatment, respectively, as compared to vehicle control. Increases in p16 protein levels could be observed in all cell lines beginning at 100nM PTC-209 and are highest at the 500nM PTC-209 dose for Abrams (120% increase) and Moresco (200% increase), but appeared to top out at 200 nM for the D17 cell line (54% increase)[3].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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