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(S,R,S)-AHPC-C6-NH2 hydrochloride

  Cat. No.:  DC40786   Featured
Chemical Structure
2360522-76-3
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Field of application
(S,R,S)-AHPC-C6-NH2 hydrochloride (VH032-C6-NH2 hydrochloride) is a synthesized?E3 ligase ligand-linker conjugate?that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C6-NH2 hydrochloride is XF038-161A, example 6, extracted from patent WO2019173516A1.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2360522-76-3
Chemical Name: (S,R,S)-AHPC-C6-NH2 hydrochloride
SMILES: [H]Cl.O=C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)[C@H](C(C)(C)C)NC(CCCCCCN)=O
Formula: C29H44ClN5O4S
M.Wt: 594.21
Purity: >98%
Sotrage: Please store the product under the recommended conditions in the Certificate of Analysis.
Description: (S,R,S)-AHPC-C5-NH2 hydrochloride (VH032-C5-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S,R,S)-AHPC-C5-NH2 hydrochloride is XF038-161A, example 6, extracted from patent WO2019173516A1[1].
Target: VHL
In Vitro: (S,R,S)-AHPC-C5-NH2 hydrochloride (VH032-C5-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader, XF038-161A, example 6, extracted from patent WO2019173516A1[1].
References: [1]. Jian Jin, et al. Serine threonine kinase (akt) degradation / disruption compounds and methods of use. Patent WO2019173516A1.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
Cat. No. Product name Field of application
DC39625 (S,R,S)-AHPC-PEG4-NH2 hydrochloride VH 032 Linker 2 is a derivative of the proteolysis-targeting chimera technology (PROTAC) building block VHL ligand 1.
DC50079 Thalidomide-O-amido-C5-NH2 Thalidomide-O-amido-C5-NH2 is a novel PROTAC building block.
DC50078 (S,R,S)-AHPC-Me-C8-NH2 (S,R,S)-AHPC-Me-C8-NH2 is a novel PROTAC building block.
DC50077 (S,R,S)-AHPC-Me-C4-NH2 (S,R,S)-AHPC-Me-C4-NH2 is a novel PROTACA building block.
DC50076 (S,R,S)-AHPC-Me-C3-NH2 (S,R,S)-AHPC-Me-C3-NH2 is a novel PROTAC building block.
DC50075 (S,R,S)-AHPC-Me-C2-NH2 (S,R,S)-AHPC-Me-C2-NH2 is a novel PROTAC building block.
DC50074 (S,R,S)-AHPC-Me-C1-NH2 (S,R,S)-AHPC-Me-C1-NH2 is a novel PROTAC Building block.
DC50070 (S,R,S)-AHPC-PEG2-NH2 (E3 ligase Ligand-Linker Conjugates 6 Free Base) (S,R,S)-AHPC-PEG2-NH2 (VH032-PEG2-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.
DC50069 (S,R,S)-AHPC-PEG4-NH2(E3 ligase Ligand-Linker Conjugates 7) (S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
DC50068 (S,R,S)-AHPC-Me-C10-NH2 (S,R,S)-AHPC-Me-C10-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-C10-NH2 can be used in PROTAC MS432
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