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S29434

  Cat. No.:  DC12622   Featured
Chemical Structure
874484-20-5
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More than 5000 active chemicals with high quality for research!
Field of application
S29434 (S 29434) is a highly potent, selective, cell-active inhibitor of Quinone reductase 2 (QR2) with IC50 of 5-16 nM, shows good selectivity for QR2 over QR1.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 874484-20-5
Chemical Name: N-(2-(2-methoxy-6H-dipyrido[2,3-a:3',2'-e]pyrrolizin-11-yl)ethyl)furan-2-carboxamide
Synonyms: S 29434;S-29434
SMILES: O1C=CC=C1C(NCCC1=C2C3=NC=CC=C3CN2C2=CC=C(OC)N=C21)=O
Formula: C21H18N4O3
M.Wt: 374.4
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Boutin JA, et al. S29434, a Quinone Reductase 2 Inhibitor: Main Biochemical and Cellular Characterization. Mol Pharmacol. 2019 Mar;95(3):269-285.
Description: S29434 (NMDPEF) is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1. S29434 (NMDPEF) induces autophagy and inhibits QR2-mediated ROS production[1].
Target: IC50: 5 nM (h QR2, expressed in E. coli, NRH as co-substrate), 16 nM (h QR2, expressed in E. coli, with BNAH as co-substrate)[1]
References: [1]. Boutin JA, et al. S29434, a Quinone Reductase 2 Inhibitor: Main Biochemical and Cellular Characterization. Mol Pharmacol. 2019 Mar;95(3):269-285.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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