SBI-0640756（SBI-756）|eIF4G1 inhibitor|CAS 1821280-29-8

Cas No.:	1821280-29-8
Chemical Name:	SBI-0640756
Synonyms:	SBI0640756;SBI 0640756;SBI-0640756
SMILES:	O=C1NC2C=CC(=CC=2C(C2C=CC=CC=2)=C1C(=O)/C=C/C1C=NC=C(F)C=1)Cl
Formula:	C₂₃H₁₄ClFN₂O₂
M.Wt:	404.82
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

SBI-0640756（SBI-756） is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. SBI-756 also suppressed AKT and NF-κB signaling. 1) SBI-756 inhibited the growth of NRAS, BRAF, and NF1-mutant melanomas . 2) SBI-756 attenuates resistance to BRAFi and inhibits NRAS- and NF1-mutant melanomas. 3) SBI-756 delayed the onset and reduced the incidence of Nras/Ink4a melanomas

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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