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SD169

  Cat. No.:  DC8512   Featured
Chemical Structure
1670-87-7
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More than 5000 active chemicals with high quality for research!
Field of application
SD169 is an orally available, ATP-competitive, isoenzyme-selective Mitogen-Activated Protein Kinase (MAPK) inhibitor.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1670-87-7
Chemical Name: 1H-​indole-​5-​carboxamide
Synonyms: 5-Carbamoylindole
SMILES: NC(C1=CC=C(NC=C2)C2=C1)=O
Formula: C9H8N2O
M.Wt: 160.2
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: SD-169 is an orally active ATP-competitive inhibitor of p38α MAPK, with an IC50 of 3.2 nM. SD-169 also weakly inhibits p38β MAPK with an IC50 of 122 nM. SD-169 prevents the development and progression of diabetes by inhibiting T cell infiltration and activation[1].
Target: p38α MAPK:3.2 nM (IC50) p38β MAPK:122 nM (IC50)
In Vitro: SD-169 significantly reduces p38 and HSP60 expression in T cells of the pancreatic beta islets[1]. SD-169 demonstrates 38-fold potency against p38α MAP kinase (IC50=3.2 nM) than p38β MAP kinase (IC50=122 nM)[1].
References: [1]. Medicherla S, et al. Preventive and therapeutic potential of p38 alpha-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes. J Pharmacol Exp Ther. 2006 Jul;318(1):99-107.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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