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SR 0987

  Cat. No.:  DC11412   Featured
Chemical Structure
303126-97-8
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Field of application
SR 0987 is an agonist of the T cell-specific isoform of RORγ (RORγt, retinoic acid receptor-related orphan receptor-γt), inducing reporter gene expression with an EC50 value of ~800 nM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 303126-97-8
Chemical Name: 2-chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzamide
Synonyms: SR 0987，SR-0987，SR0987，303126-97-8
SMILES: ClC1=CC=CC=C1C(NC2=CC=C(C(C(F)(F)F)(C(F)(F)F)O)C=C2)=O
Formula: C16H10ClF6NO2
M.Wt: 397.7
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: SR0987 is a RORγt agonist, with an EC50 of 800 nM.
In Vitro: SR0987 clearly shows a concentration dependent induction of reporter gene expression with an EC50 of ~800nM. SR0987 treatment results in a statistically significant reduction of the surface expression of PD-1 whereas desmostrol treatment shows no effect. Treatment with SR0987 and or desmosterol results in a trend towards increased IL17 production[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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