Cas No.: | 1164470-53-4 |
Chemical Name: | Sal-003,SAL 003,SAL003 |
Synonyms: | Sal-003,SAL 003,SAL003 |
SMILES: | O=C(C=CC1C=CC=CC=1)NC(C(Cl)(Cl)Cl)NC(=S)NC1C=CC(Cl)=CC=1 |
Formula: | C18H15Cl4N3Os |
M.Wt: | 463.21 |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | Sal003 is a potent cell-permeable analog of the eIF2α phosphatase inhibitor Salubrinal with enhanced aqueous solubility.IC50 value:Target: eIF2α phosphatase inhibitorSal003 has been shown to prevent dephosphorylation of eIF-2α which has been shown to regulate the late phase of long-term potentiation (LTP) and memory (LTM). This enhanced phosphorylated state of eIF-2α is shown to prevent L-LTP and suppress memory in mice. |