TD-0212|TD0212;TD 0212

Cas No.:	1073549-10-6
Chemical Name:	(S)-4'-((2-ethoxy-4-ethyl-5-((2-mercapto-4-methylpentanamido)methyl)-1H-imidazol-1-yl)methyl)-3'-fluoro-[1,1'-biphenyl]-2-carboxylic acid
Synonyms:	TD0212;TD 0212
SMILES:	C(C1=CC=C(CN2C(OCC)=NC(CC)=C2CNC(=O)[C@H](S)CC(C)C)C(F)=C1)1=CC=CC=C1C(O)=O
Formula:	C₂₈H₃₄FN₃O₄S
M.Wt:	527.655
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

TD-0212 (TD0212) is a potent, orally efficacious, dual AT1 antagonist/Neprilysin (NEP) inhibitor with pKi of 8.9 (AT1) and pIC50 of 9.2 (NEP); produces blood pressure reductions similar to omapatrilat and combinations of AT1 receptor antagonists and NEP inhibitors in models of renin-dependent and -independent hypertension, does not increase TPE at antihypertensive doses in rat tracheal plasma extravasation (TPE) models.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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