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THIACETAZONE

  Cat. No.:  DC7517   Featured
Chemical Structure
104-06-3
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Field of application
A thiosemicarbazone that is used in association with other antimycobacterial agents in the initial and continuation phases of antituberculosis regimens. Thiacetazone containing regimens are less effective than the short-course regimen recommended by the I
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 104-06-3
Chemical Name: N-[4-[(E)-(carbamothioylhydrazinylidene)methyl]phenyl]acetamide
Synonyms: AMITHIOZONE, Thiacetazone, Conteben, Benzothiozane, Thioacetazon, Ambathizon, Parazone, Tibon, Tubin
SMILES: CC(NC1=CC=C(/C=N/NC(N)=S)C=C1)=O
Formula: C10H12N4Os
M.Wt: 236.29
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Thiacetazone (Thioacetazone) is a thiourea-containing antitubercular agent and is an orally active antibiotic. Thiacetazone has antibacterial action, which inhibits growth of Mycobacterium tuberculosis H37Rv with a MIC value of 0.1 μg/mL[1].
In Vivo: The Km and Vmax values for the N-deacetylation of Thiacetazone are 0.57 mM and 0.123 nmol of p-aminobenzaldehydethiosemicarbazone formed/min/mg cytosolic protein, respectively. The ability to metabolize Thiacetazone is the same in the livers of cat, mouse and human, but lagged significantly in that of rat[2].
In Vitro: Thiacetazone is a prodrug that is activated by the mycobacterial monooxygenase EthA, which is also the activator of two other anti-tuberculosis agents, Ethionamide and Isoxyl[3].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
Cat. No. Product name Field of application
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