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Tegaserod (maleate)

  Cat. No.:  DC9315   Featured
Chemical Structure
189188-57-6
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Field of application
Tegaserod maleate is a partial agonist of the 5-HT4 receptor; stimulates the peristaltic reflex and accelerates gastrointestinal transit.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 189188-57-6
Chemical Name: Tegaserod
Synonyms: Tegaserod;TEGASEROD MALEATE;2-[(5-methoxy-1h-indole-3-yl)methylene]-n-pentylcarbazimidamide hydrogen maleate;2-[(5-methoxy-1h-indol-3-yl)methylene]-n-pentylhydrazine-carboximidamide;Tegaserode;HTF-919;SDZ-HTF-919;2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentyl-hydrazinecarboximidamide maleate;2-[(5-Methoxy-1H-indole-3-yl)methylene]-N-pentylcarbazimidamide hydrogen maleate;ZELMAC;HTF 919;ZelnorM;Tegibs 6;Toromifene;TegaserodMalate;TegastrodMaleate;Tegaserod Hydrogen Maleate
SMILES: CCCCCNC(N/N=C/C1=CNC2=CC=C(C=C12)OC)=N
Formula: C16H23N5O
M.Wt: 301.386722803116
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Tegaserod maleate is a partial agonist of the 5-HT4 receptor; stimulates the peristaltic reflex and accelerates gastrointestinal transit. In an in vivo model for peripheral nerve regeneration, mice receiving tegaserod at the site of injury showed enhanced recovery compared to control mice receiving vehicle control as evidenced by functional measurements and histology [1]. Treatment with fluoxetine (10 mg · kg(-1) · day(-1), days 36-42), tegaserod (1 mg · kg(-1) · day(-1), day 43), or the combination of both, reduced visceral hypersensitivity and plasma 5-HT levels [2]. Intravenous or intraduodenal tegaserod (0.3-1.0 mg.kg(-1)) had no inhibitory effect on mesenteric and colonic blood flow. Peroral treatment of rats with alosetron or tegaserod for 7 days did not modify mesenteric haemodynamics at baseline and after blockade of nitric oxide synthesis [3].
Target: -HT4 agonist
References: [1]. Bushman J, et al. Tegaserod mimics the neurostimulatory glycan polysialic acid and promotes nervous system repair. Neuropharmacology. 2014 Apr;79:456-66. [2]. Yan C, et al. Effect of the 5-HT4 receptor and serotonin transporter on visceral hypersensitivity in rats. Braz J Med Biol Res. 2012 Oct;45(10):948-54. [3]. Painsipp E, et al. Alosetron, cilansetron and tegaserod modify mesenteric but not colonic blood flow in rats. Br J Pharmacol. 2009 Nov;158(5):1210-26.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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