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F13714 fumarate

  Cat. No.:  DC45564   Featured
Chemical Structure
208109-39-1
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Field of application
F13714 fumarate, a selective 5-HT1A receptor biased agonist, shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 208109-39-1
Chemical Name: F13714 fumarate
Synonyms: F13714 fumarate;(E)-but-2-enedioic acid;(3-chloro-4-fluorophenyl)-[4-fluoro-4-[[[5-methyl-6-(methylamino)pyridin-2-yl]methylamino]methyl]piperidin-1-yl]methanone
SMILES: ClC1=C(C([H])=C([H])C(=C1[H])C(N1C([H])([H])C([H])([H])C(C([H])([H])N([H])C([H])([H])C2C([H])=C([H])C(C([H])([H])[H])=C(N([H])C([H])([H])[H])N=2)(C([H])([H])C1([H])[H])F)=O)F.O([H])C(/C(/[H])=C(\[H])/C(=O)O[H])=O
Formula: C25H29ClF2N4O5
M.Wt: 538.9714
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: F13714 fumarate, a selective 5-HT1A receptor biased agonist, shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress[1].
Target: 5-HT1A Receptor
In Vivo: In UCMS mice, a single administration of F13714 (4–16 mg/kg) is sufficient to robustly normalize depressive-like behavior in the forced swim test (FST). F13714 rescues cortical and hippocampal deficits in p-ERK1/2 levels but does not influence the p-CREB levels[1]. F13714 decreases the immobility in mice at the doses 2 and 4 mg/kg by 30.3% and 19.5%[1]. F13714 (0.5-2 mg/kg) given alone significantly and dose-dependently decreases rectal body temperature in mice during a 2-h measurement[1]. F13714 (2.5 mg/kg) possess antidepressant-and anxiolytic-like properties in naïve rats[1].
In Vitro: F13714 targets 5-HT1A autoreceptors[1].
References: [1]. Monika Głuch-Lutwin, et al. The selective 5-HT 1A receptor biased agonists, F15599 and F13714, show antidepressant-like properties after a single administration in the mouse model of unpredictable chronic mild stress. Psychopharmacology (Berl). 2021 May 10.
MSDS
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2018-0101
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