Tyrphostin 9（AG-17）|cas 10537-47-0|DC Chemicals

Cas No.:	10537-47-0
Chemical Name:	Malonoben
Synonyms:	Propanedinitrile,2-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-;Tyrphostin 9;Tyrphostin A9;2-(3,5-Di-tert-butyl-4-hydroxybenzylidene)malononitrile;2-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile;AG-17;malonoben;SF 6847;[(3,5-di-tert-butyl-4-hydroxyphenyl)methylidene]propanedinitrile;2-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile;3,5-di-tert-butyl-4-hydroxybenzylidene-malononitrile;AG 17;AG9;AG-9;Caswell No. 291AA;GCP 5126;Tyrphostin AG17;NSC 242557;RG-50872;[[3,5-bis(1,1-Dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile;[4-Hydroxy-3,5-bis(2-methyl-2-propanyl)benzylidene]malononitrile;3,5-di-tert-Butyl-4-hydroxybenzylidenemalonitrile;2,6-Di-tert-butyl-4-(2,2-dicyanovinyl)phenol;RG 50872;s-15126;ent27910;MALONABEN;Malonobene;Tyrphostin A 9;Tyrphostin AG 17;gcp5126;Malonoben [ANSI];ENT 27910;Tyrphostin 9/AG-9;(3,5-Di-t-butyl-4-hydroxybenzylidene)malononitrile;EPA Pesticide Chemical Code 537200;3,5-di-t-Butyl-4-hydroxy-benzylidenemalononitrile;MLS002702095;87TE8MRS65;2-[(3,5-di-tert-butyl-4-hydroxyphenyl)methylidene]p
SMILES:	O([H])C1C(=C([H])C(/C(/[H])=C(\C#N)/C#N)=C([H])C=1C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
Formula:	C₁₈H₂₂N₂O
M.Wt:	282.3801
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Tyrphostin A9(AG 17), a tyrosine kinase inhibitor, is a potent inducer of mitochondrial fission. Tyrphostin A9 emerged as the most potent and selective of 51 tyrosine kinase inhibitors tested against the TNF-induced respiratory burst.

References:

[1]. Park SJ, Park YJ, Shin JH, et al. A receptor tyrosine kinase inhibitor, Tyrphostin A9 induces cancer cell death through Drp1 dependent mitochondria fragmentation. Biochem Biophys Res Commun. 2011 May 13;408(3):465-70. [2]. Richard F. Loeser, Christopher B. Forsyth, Allen M. Samarel et al. Fibronectin Fragment Activation of Proline-rich Tyrosine Kinase PYK2 Mediates Integrin Signals Regulating Collagenase-3 Expression by Human Chondrocytes through a Protein Kinase C-dependent Pathway. The Journal of Biological Chemistry, 2003, 278, 24577-24585. [3]. Michele Fuortes, Maxine Melchior, Hyunsil Han, et al. Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF. J Clin Invest. 1999;104(3):327-335. [4]. Johan Thyberg . Tyrphostin A9 and wortmannin perturb the Golgi complex and block proliferation of vascular smooth muscle cells. European Journal of Cell Biology.1998,76(1): 33-42 [5]. R Marhaba, F Mary, C Pelassy, et al. Tyrphostin A9 inhibits calcium release-dependent phosphorylations and calcium entry via calcium release-activated channel in Jurkat T cells. The Journal of Immunology. 1996,157 (4): 1468-1473

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
DC70520	JBJ-09-063	JBJ-09-063 is a potent, mutant-selective allosteric EGFR inhibitor against EGFR L858R, T790M and C797S mutations, with IC50 of <0.1 nM for recombinant EGFR L858R/T790M kinase domain.
DC40932	JCN037	JCN037 (JGK037) is non-covalent and BBB-penetrant EGFR tyrosine kinase inhibitor, with IC50 values of 2.49 nM, 3.95 nM, 4.48 nM for EGFR, p-wtEGFR and pEGFRvⅢ, respectively.
DC7622	BIBX1382	BIBX 1382 is a potent, selective inhibitor of EGFR tyrosine kinase (IC50 = 3 nM); displays > 1000-fold lower potency against ErbB2 (IC50 = 3.4 μM) and a range of other related tyrosine kinases (IC50 > 10 μM).
DC12161	TAS6417	TAS6417 is an EGFR inhibitor and an efficacious drug candidate for patients with NSCLC, with IC50 values ranging from 1.1-8.0 nM.
DC10764	Theliatinib (HMPL-309)	Theliatinib (HMPL-309) is a novel small molecule, EGFR tyrosine kinase inhibitor with potential antineoplastic and anti-angiogenesis activities.
DC5090	WZ4002	WZ4002 is a novel, mutant-selective EGFR inhibitor for EGFR(L858R)/(T790M) with IC50 of 2 nM/8 nM; does not inhibit ERBB2 phosphorylation (T798I).
DC9775	WZ3146	WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I).
DC10519	SU 5214	SU 5214 is a modulator of tyrosine kinase signal transduction.
DC7078	AZD-8931(Sapitinib)	Sapitinib(AZD8931) is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM respectively.
DC10479	RX518(CK-101:EGFR-IN-3)	RX518(CK-101) is an orally available third-generation and selective inhibitor of certain epidermal growth factor receptor (EGFR) activating mutations.