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Ulixertinib (BVD-523, VRT752271)

  Cat. No.:  DC7557   Featured
Chemical Structure
869886-67-9
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Field of application
Ulixertinib, also known as BVD-523 and VRT752271, is an inhibitors of ERK protein kinase.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 869886-67-9
Chemical Name: (S)-4-(5-chloro-2-(isopropylamino)pyridin-4-yl)-N-(1-(3-chlorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamide.
Synonyms: BVD-523, BVD 523, BVD523, VRT752271, VRT752271, VRT 752271, Ulixertinib
SMILES: N1C(C(=O)N[C@H](CO)C2C=C(Cl)C=CC=2)=CC(C2=CC(NC(C)C)=NC=C2Cl)=C1.Cl
Formula: C21H22Cl2N4O2
M.Wt: 433.33
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Ulixertinib (VRT752271) is a reversible, ATP-competitive inhibitor of ERK1 and ERK2 kinases, with IC50 of <0.3 nM against ERK2.
In Vivo: In the pharmacokinetic study, the sensitivity and specificity of the assay are found to be sufficient for accurately characterizing the plasma pharmacokinetics of Ulixertinib in Balb/C mice[1].
In Vitro: Ulixertinib (VRT752271) is a reversible, ATP-competitive inhibitor of ERK1 and ERK2 kinases, with IC50 of <0.3 nM against ERK2[2].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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