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C5 complement inhibitor 7

  Cat. No.:  DC70280  
Chemical Structure
2365402-67-9
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More than 5000 active chemicals with high quality for research!
Field of application
C5 complement inhibitor 7 (C5-IN-7) is a potent, small-molecule inhibitor of C5 complement protein with serum assay IC50 of <5 nM (2% human serum complement inhibition).C5-IN-7 demonstrated excellent potency and good aqueous solubility, inhibited MAC deposition with IC50 of 1 uM in a complement inhibition assay using 50% human whole blood.The C5 triple mutants (C704R, V705I and N707H) were not inhibited by C5 complement protein inhibitor 7 up to 100 uM.C5 complement protein inhibitor 7 binds within the predicted pocket between the C5a and MG8 domains in close proximity to the C5 convertase cleavage site (R751-L752).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2365402-67-9
Chemical Name: C5 complement inhibitor 7
Synonyms: C5 complement-IN-7
Formula: C24H32N2O6
M.Wt: 444.528
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC72349 CP-447697 CP-447697 is a lipophilic C5a receptor antagonist with an IC50 value of 31 nM. CP-447697 can be used for the research of inflammation.
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DC11082 Danicopan (ACH-4471) Danicopan (ACH-4471, ACH-0144471) is a highly potent, orally active Factor D inhibitor with Kd of 0.54 nM, inhibits the proteolytic activity of purified Factor D against substrate Factor B in complex with C3b, blocking production of Bb fragment IC50 of 15 nM.
DC11688 Avacopan Avacopan is a potent, selective, orally availale C5aR (CD88) inhibitor with IC50 of 0.1 nM.
DC73517 WWGKKYRASKLGLAR Peptide WWGKKYRASKLGLAR is a super agonist of complement factor C3aR, 12-15 times more active than natural C3a.
DC73516 T-ALZ01 T-ALZ01 (CMP-1696) is a small molecule inhibitor of complement component C1r.
DC73515 DF3016A DF3016A (DF 3016A) is a potent and selective C5aR inhibitor with IC50 of 50 nM (C5a-induced human PMN migration and IC50 of 45 and 37 nM against rat and mouse C5aR, respectively.
DC73514 CMP-1611 CMP-1611 is a small molecule inhibitor of protease of the complement classical pathway, C1r, directly inhibits classical pathway-specific complement activation in a dose-dependent manner.
DC71782 Pelecopan Pelecopan (BCX9930) is a potent, selective, orally active inhibitor of complement factor D with an IC50 value of 14.3 nM. Pelecopan can target factor D to prevent both intravascular and extravascular hemolysis in PNH. Pelecopan also be used for other alternative pathway (AP) mediated diseases.
DC70527 JPE1375 JPE1375 is a potent, peptidomimetic C5a receptor antagonist with IC50 of 39 nM.JPE1375 inhibits neutrophil influx in the RPAR in mice.
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