Danicopan (ACH-4471)
Cat. No.: DC11082
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Chemical Structure
1903768-17-1
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Field of application
Danicopan (ACH-4471, ACH-0144471) is a highly potent, orally active Factor D inhibitor with Kd of 0.54 nM, inhibits the proteolytic activity of purified Factor D against substrate Factor B in complex with C3b, blocking production of Bb fragment IC50 of 15 nM.
| Cas No.: |
1903768-17-1 |
| Chemical Name: |
(2S,4R)-1-{[3-acetyl-5-(2-methylpyrimidin-5-yl)-1H-indazol1-yl]acetyl}-N-(6-bromopyridin-2-yl)-4-fluoropyrrolidine2-carboxamide |
| Synonyms: |
ACH-4471;ACH4471;ACH-0144471 |
| SMILES: |
N(C(CN1C2=C(C=C(C3=CN=C(C)N=C3)C=C2)C(C(C)=O)=N1)=O)1C[C@@H](F)C[C@@H]1C(NC1=NC(Br)=CC=C1)=O |
| Formula: |
C26H23BrFN7O3 |
| M.Wt: |
580.418 |
| Purity: |
>98% |
| Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: |
Danicopan, a selective and orally active small-molecule factor D inhibitor, inhibits alternative pathway of complement (APC) activity. Danicopan has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS)[1]. |
| Target: |
Factor D[1] |
| References: |
[1]. https://www.ncbi.nlm.nih.gov/pubmed/28416568 |
MSDS
COA
| LOT NO. |
DOWNLOAD |
|
|
| 2018-0101 |
|
| 2018-0101 |
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