Elezanumab
Cat. No.: A459
Featured
Chemical Structure
1791416-49-3
We are official vendor of:
More than 5000 active chemicals with high quality for research!
Field of application
Elezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway, with an IC50 around 97 pM. Elezanumab promotes neuroregeneration and neuroprotection in neuronal injury and demyelination models binds N-terminal RGMa, blocks BMP signaling and lacks RGMc cross-reactivity. elezanumab has neuroregenerative and neuroprotective activities without impact on iron metabolism.
| Cas No.: |
1791416-49-3 |
| pH value: |
Corresponds to reference standard: PASS |
| Non-reduced CE-SDS: |
>95% |
| SEC-HPLC: |
>95% |
| Isoelectric Point: |
Corresponds to reference standard |
| Osmolality: |
Corresponds to reference standard: PASS |
| Peptide mapping: |
Corresponds to reference standard: PASS |
| N-terminal sequence: |
Corresponds to reference standard: PASS |
Get Quote
