| DC41887 |
Cortagine
|
Cortagine is a specific corticotropin-releasing factor receptor subtype 1 (CRF1) agonist with an IC50 of 2.6 nM for rCRF1. Cortagine is an anxiolytic and antidepressive drug in the mouse model. |
| DC11104 |
Tildacerfont
|
corticotropin releasing factor (CRF) antagonist. |
| DC73414 |
NBI-35965
|
NBI-35965 is a potent, selective antagonist of corticotropin-releasing factor 1 (CRF1) receptor with Ki of 4 nM, >1000-fold selective over CRF2. |
| DC73413 |
NBI-27914
|
NBI-27914 is a potent, selective antagonist of corticotropin-releasing factor 1 (CRF1) receptor with Ki of 1.7 nM, shows no activity at CRF2 receptors. |
| DC73412 |
BMK-C205
|
BMK-C205 (BMK-C 205) is a potent, selective corticotropin-releasing hormone receptor 1 (CRF1R) antagonist with IC50 of 74 nM in calcium mobilization assays, blocks hypothalamus-pituitary-adrenal (HPA) axis activation. |
| DC70110 |
(R)-LMI
|
(R)-LMI (H2N-R-Leu-Met-Ile-COOH) is a tripeptide analogue of corticotropin-releasing factor (CRF) and CRF antagonist targeting the N-domain of CRF1 receptor;
(R)-LMI inhibits CRF-stimulated cAMP accumulation with IC50 of 1.7 uM.
(R)-LMI inhibits the production of interleukins by adipocytes and the proliferation rate of RAW 264.7 cells. |
