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PDE-I2

  Cat. No.:  DC70681  
Chemical Structure
98296-23-2
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More than 5000 active chemicals with high quality for research!
Field of application
PDE-I2 is a potent and selective inhibitor of malaria proliferation with Pf IC50 of 18 nM.PDE-I2 is a precursor of the anticancer duocarmycin family that preserves the class's sequence-specific DNA binding but lacks its signature DNA alkylating cyclopropyl warhead.PDE-I2 retains comparable antimalarial potency to chloroquine.PDE-I2 is >1,000-fold less toxic to human cell lines than duocarmycin, with mitigated impacts on eukaryotic chromosome stability.PDE-I2 treatment induces severe defects in parasite nuclear segregation leading to impaired daughter cell formation during schizogony.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 98296-23-2
Chemical Name: PDE-I2
Formula: C25H23N5O8
M.Wt: 521.486
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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