PSI-353661

  Cat. No.:  DC72291  
Chemical Structure
1231747-08-2
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More than 5000 active chemicals with high quality for research!
Field of application
PSI-353661 (GS-558093) is a purine nucleotide NS5B polymerase inhibitor against HCV infection (EC90: 8 nM). PSI-353661 can produce high concentrations of the active triphosphate in primary human hepatocytes.
Cas No.: 1231747-08-2
Chemical Name: PSI-353661
SMILES: COC1=NC(N)=NC2=C1N=CN2[C@@H]([C@@](F)(C)[C@@H]3O)O[C@@H]3CO[P@@](N[C@@H](C)C(OC(C)C)=O)(OC4=CC=CC=C4)=O
Formula: C24H32FN6O8P
M.Wt: 582.52
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_36742_DC72291_1231747-08-2
COA
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Cat. No. Product name Field of application
DC46625 HCV-IN-30 HCV-IN-30 (compound 48) is a HCV NS5A replication complex inhibitor, with IC50s of 901 and 102 nM for genotypes 1a and 1b replicons, respectively.
DC1008 Telaprevir (VX-950) Telaprevir (VX-950) is an HCV NS3-4A serine protease inhibitor with IC50 of 0.35 μM.
DC9463 Tegobuvir (GS-9190; GS 333126) Tegobuvir (GS-9190; GS 333126) is a non-nucleoside nonstructural protein (NS)5B polymerase inhibitor.
DC9462 R-7128(Mericitabine) R-7128(Mericitabine) is a selective nucleoside analog inhibitor of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, with activity across all HCV genotypes.
DC72543 CL-197 CL-197 is an orally active and long-acting purine anti-HIV nucleoside reverse transcriptase inhibitor (NRTI). CL-197 has potential effect on the research of viral, oncological and cerebrovascular diseases.
DC72542 XZ426 XZ426 is a potent integrase strand transfer inhibitor with anti- < a href="https://www.medchemexpress.cn/Targets/HIV.html" class="link-product" target="_blank">HIVactivity.
DC72538 GS-9256 GS-9256 is a selective HCV NS3 protease inhibitor. GS-9256 has good pharmacokinetic properties and antiviral activity.
DC72291 PSI-353661 PSI-353661 (GS-558093) is a purine nucleotide NS5B polymerase inhibitor against HCV infection (EC90: 8 nM). PSI-353661 can produce high concentrations of the active triphosphate in primary human hepatocytes.
DC72152 2'-C-Methyladenosine 2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication. 2'-C-Methyladenosine inhibits HCV replicon and NS5B-catalyzed RNA synthesis with IC50 values of 0.3μM and 1.9 μM, respectively. 2'-C-Methyladenosine also potently inhibits LRV1 in Leishmania guyanensis (Lgy) and Leishmania braziliensis.
DC71964 Paritaprevir dihydrate Paritaprevir (ABT-450) dihydrate is a potent, orally active and antiviral non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50s of 1 and 0.21 nM against HCV 1a and 1b, respectively. Paritaprevir dihydrate is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.31 μM. Paritaprevir dihydrate is metabolized primarily by cytochrome P450 (CYP) 3A. The plasma concentration and half-life of Paritaprevir dihydrate can be enhanced by Ritonavir (a CYP450 inhibitor).
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