DC82301 |
IC-8
|
IC8 is an ionizable cationic lipid. It has been used in combination with other lipids for the formation of lipid nanoparticles (LNPs). Immunization with severe acute respiratory coronavirus 2 (SARS-CoV-2) spike glycoprotein mRNA in IC8- and manganese-containing LNPs induces IgG responses to SARS-CoV-2 Delta and Omicron variants in mice.1 Administration of mRNA encoding B7-H3 X CD3 bispecific T cell engaging (BiTE) antibodies in IC8-containing LNPs reduces tumor growth in MV4-11 and A375 mouse xenograft models. |
DCC4995 |
Szu101
|
Novel TLR7 agonist via immune response induction and tumor microenvironment modulation |
DCC3219 |
Malp-2
|
Toll-like receptor 2/6 (TLR-2/6) agonist, regulating Lcn2 gene, promoting collateral growth |
DC72823 |
SU056
|
SU056 is an inhibitor of Y box binding protein 1 (YB-1) with IC50 of 1.73 μM in Sk0V3 cells. |
DC72724 |
PTC258
|
PTC258 is a specific and orally active splicing modulator of Elongator complex protein 1 gene (ELP1). PTC258 increases the expression of ELP1 in vitro and in vivo. PTC258 is well tolerated in mouse model. |
DC72551 |
BT5
|
BT5 is an irreversible inhibitor of SET domain of nuclear receptor-binding SET domain 1 (NSD1) histone methyltransferase. |
DC72507 |
VT-1598 tosylate
|
VT-1598 tosylate is an orally active and selective fungal inhibitor targeting CYP51. VT-1598 tosylate shows anti-fungal activity against C. auris. |
DC72432 |
DSPE-N3
|
DSPE-N3 is a lipid. DSPE-N3 can be used for the research of various biochemical. |
DC72429 |
DSPE-glutaric acid
|
DSPE-glutaric acid is a lipid. DSPE-glutaric acid can be used for the research of various biochemical. |
DC71975 |
TriGalNAc CBz
|
TriGalNAc CBz is a GalNAc derivative and tri-GalNAc is an asialoglycoprotein receptor (ASGPR) ligand. TriGalNAc CBz can be used for mRNA drug delivery as well as lysosomal targeted chimerism (LYTAC) studies. |