Bendamustine HCL (SDX-105, Cytostasane)|supplier DC Chemicals

Cas No.:	3543-75-7
Chemical Name:	Bendamustine hydrochloride
Synonyms:	4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid hydrochloride;BENDAMUSTIN HYDROCHLORIDE;CYTOSTASAN;1-methyl-5-bis(2-chloroethyl)amino-2-benzimidazolinebutryric acid hydrochloride;4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid hydrochloride;1-methyl-5-bis(2-chloroethyl)amino-2-benzimidazolinebutryricacihydrochlor;gamma(1-methyl-5-bis(beta-chloraethyl)aminobenzimidazoyl-2)buttersaeurehydro;BENDAMUSTINE HCL;4-[5-[Bis(2-chloroethyl)amino]-1-methyl-benzimidazol-2-yl]butyric acid hydrochloride;Bendamustine hydrochloride hydrate;4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo-[d]imidazol-2-yl)butanoic acid hydrochloride;Bendamustine hydrochloride;REMODULIN;BendaMustin HCl;Bendamustinhydrochlorid;Bendamustinum;CytostasanHCl;EP3101;EP-3101;Ribomustin;SDX105;SDX-105;Treanda;ZIMET-33;IMET 3393;Treakisym;Bendamustine (hydrochloride);Bendeka;SDX 105;981Y8SX18M;Ribomustine;Levact;Treanda (TN);gamma(1-Methyl-5;1H-Benzimidazole-2-butanoic acid, 5-(bis(2-chloroethyl)amino)-1-methyl-, monohydrochloride;NCGC00261308-01;BENDAMUSTINE HYDROCHLORIDE [MI];BCP02107;Hydrochloride, Bendamustine;2-Benzimidazolebutyric acid, monohydrochloride;Ribomustin (TN);Cytostasan Hydrochloride;CHEMBL1201734;VIVIMUSTA;4-[5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-yl]butanoic acid monohydrochloride;Bendamustine HCL (SDX-105, Cytostasane);SCHEMBL18843;2-Benzimidazolebutyric acid, 5-(bis(2-chloroethyl)amino)-1-methyl-, monohydrochloride;BENDAMUSTINE HYDROCHLORIDE [USP-RS];Bendamustin hydrochloride;BCP9000390;BENDAMUSTINE HYDROCHLORIDE (MART.);AS-15856;Belrapzo;HY-B0077;Z2235802251;2-Benzimidazolinebutryric acid, hydrochloride;Cytostasan;Bendamustine Hydrochloride Injection;NSC-138783;AKOS015951203;Cytostosan;4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzoimidazol-2-yl)butanoic acid monohydrochloride;Fmoc-(S)-3-Amino-3-(3-trifluoromethyl-phenyl)-propionicacid;SW219266-1;Bendit;Bendamustine HCl;BENDAMUSTINE HYDROCHLORIDE (USP-RS);CS-1771;5-[Bis(2-chloroethyl)-amino]-1-methyl-1H-benzimidazole-2-butanoic Acid Hydrochloride;Ribomustin HCl;FT-0650624;2-Benzimidazolinebutryric acid, 1-methyl-5-bis(2-chloroethyl)amino-, hydrochloride;SMR004234484;BCPP000348;BENDAMUSTINE HYDROCHLORIDE [WHO-DD];4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoicacidhydrochloride;Treanda HCl;MLS006010156;AM20090666;Bendamustine hydrochloride [USAN:JAN];Symbenda;NSC 138783;CCG-221927;BENDAMUSTINE HYDROCHLORIDE (USP MONOGRAPH);5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid hydrochloride;SyB L-0501;1H-Benzimidazole-2-butanoic acid, 5-[bis(2-chloroethyl)amino]-1-methyl monohydrochloride;MFCD01658758;5-[Bis(2-chloroethyl)amino]-1-methylbenzimidazole-2-butyric Acid Hydrochloride;B4033;3543-75-7 (HCl);BENDAMUSTINE HYDROCHLORIDE [USAN];SB17462;ZIMET 33/93;BP-25399;1H-Benzimidazole-2-butanoic ...
SMILES:	ClC([H])([H])C([H])([H])N(C([H])([H])C([H])([H])Cl)C1C([H])=C([H])C2=C(C=1[H])N=C(C([H])([H])C([H])([H])C([H])([H])C(=O)O[H])N2C([H])([H])[H].Cl[H]
Formula:	C₁₆H₂₂Cl₃N₃O₂
M.Wt:	394.7238
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Bendamustine hydrochloride is the hydrochloride salt of bendamustine, a bifunctional mechlorethamine derivative with alkylator and antimetabolite activities. Bendamustine possesses three active moieties: an alkylating group; a benzimidazole ring, which may act as a purine analogue; and a butyric acid side chain. Although its exact mechanism of action is unknown, this agent appears to act primarily as an alkylator. Bendamustine metabolites alkylate and crosslink macromolecules, resulting in DNA, RNA and protein synthesis inhibition, and, subsequently, apoptosis. Bendamustine may differ from other alkylators in that it may be more potent in activating p53-dependent stress pathways and inducing apoptosis; it may induce mitotic catastrophe; and it may activate a base excision DNA repair pathway rather than an alkyltransferase DNA repair mechanism. Accordingly, this agent may be more efficacious and less susceptible to drug resistance than other alkylators. Bendamstine was approved in USA in March 2008.For the detailed information of Bendamustine HCL (SDX-105, Cytostasane), the solubility of Bendamustine HCL (SDX-105, Cytostasane) in water, the solubility of Bendamustine HCL (SDX-105, Cytostasane) in DMSO, the solubility of Bendamustine HCL (SDX-105, Cytostasane) in PBS buffer, the animal experiment (test) of Bendamustine HCL (SDX-105, Cytostasane), the cell expriment (test) of Bendamustine HCL (SDX-105, Cytostasane), the in vivo, in vitro and clinical trial test of Bendamustine HCL (SDX-105, Cytostasane), the EC50, IC50,and Affinity of Bendamustine HCL (SDX-105, Cytostasane), Please contact DC Chemicals.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC33635	DODAP	DODAP, also known as 1,2-Dioleoyl-3-dimethylammonium-propane, is a cationic lipid. It has been used as a component in liposomes that can be used to encapsulate siRNA, immunostimulatory oligodeoxynucleotides, antisense oligonucleotides, or chemotherapeutic agents for in vitro and in vivo delivery.
DC31074	Isopropyl myristate	Isopropyl myristate is the ester of isopropyl alcohol and myristic acid.
DC74557	PREX-in1	PREX-in1 is a specific small-molecule inhibitor of P-Rex1 and P-Rex2 Rac-GEF activity with IC50 of 4.5 uM (P-Rex1 DHPH Rac-GEF activity) in liposome-based GEF assay, inhibits P-Rex1 and P-Rex2 through their catalytic DH domain.
DC74555	GYS32661	GYS32661 (GYS 32661) is a potent Rac inhibitor capable of inhibiting both Rac1 and Rac1b, inhibited activated Rac1 with IC50 of 1.18 uM in in vitro pull-down assays.
DC74539	L557-0155	L557-0155 is a small molecule inhibitor of VSIG-8, prevents VSIG-8 binding to VISTA, promotes cytokine production and cell proliferation in PBMCs and suppresses melanoma growth.
DC74528	K284	K284 is a selective small molecule inhibitor of chitinase 3 like1 (CHI3L1) with strong binding affinity (Kd=-9.7 kcal·mol-1), inhibits lung metastasis by blocking IL-13Rα2-mediated JNK-AP-1 signals.
DC74225	YB-537	YB-537 (YB537) is a potent, highly specific quinone reductase 2 (QR2) inhibitor with IC50 of 3 nM, shows no activity against QR1 (IC50>10 uM).
DC74218	UT-59	UT-59 is a specific inhibitor of cholesterol-sensing membrane protein Scap, binds to Scap's cholesterol-binding site, blocks SREBP activation and inhibits lipid synthesis.
DC74205	Tryptolinamide	Tryptolinamide (TLAM) is a small-molecule compound that activates mitochondrial respiration in cybrids generated from patient-derived mitochondria and fibroblasts from patient-derived iPSCs, inhibits phosphofructokinase-1 (PFK1) with an ATP-uncompetitive
DC74198	TMX-4102	TMX-4102 (TMX4102) is a highly potent, selective PIP4K2C binder with KD of 0.45 nM, shows no affinity for PIP4K2B and PIP4K2A (KD>10 uM).